Comparing IV fluids for treating migraines in children
Official title: Value of Intravenous Fluids in the Emergent Treatment of Pediatric Migraine
Run by Dayton Children's Hospital · NCT06182098 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if giving kids with migraines a big dose of IV fluids helps them feel better compared to a smaller amount of fluids.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 5 Years to 21 Years |
| Sex | All |
| Enrollment | 134 (estimated) |
| Sponsor | Dayton Children's Hospital Academic / other |
| Locations | 1 site (Dayton, Ohio) |
| Trial ID | NCT06182098 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include pediatric patients with a history of migraines who meet specific pain and symptom criteria.
✕Probably not a fit
Patients with conditions such as shunted hydrocephalus, significant dehydration, or those with a recent history of head trauma may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of intravenous (IV) fluids in alleviating migraine pain in pediatric patients. Participants will be randomly assigned to receive either a large bolus of normal saline or a smaller amount of fluids over a one-hour period. Pain levels will be monitored using a visual analog scale, along with vital signs checked every 30 minutes for two hours. The study seeks to determine if a larger volume of fluids can improve pain relief and reduce hospital admissions for migraine treatment.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for children suffering from migraines.
How similar studies have gone: While the approach of using IV fluids for migraine treatment is not widely tested in children, similar studies in adults have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 1 prior headache * Minimum pain score of 10mm * Headache lasting 2-72 hours * At least two of the following four: 1 Bifrontal/bitemporal or unilateral location, 2 Pulsating quality, 3 Moderate or severe pain intensity, 4 Aggravation by or causing avoidance of routine physical activity * At least one of the following: 1 Nausea and/or vomiting, 2Photophobia and phonophobia, 3 Not better accounted for by another ICHD-3 diagnosis Exclusion Criteria: * Shunted hydrocephalus * Temperature equal to or greater than 38.5C * Clinical suspicion of meningitis * Known or suspected intracranial lesion * Clinical evidence of significant dehydration (or signs of shock, or attending discretion) * Head trauma in previous 7 days * Pregnancy or breastfeeding * Initial pain score less than 10mm * Allergy to study medications * Patients previously participating in the study
Where it's running
-
Dayton Children's Hosptial
Dayton, Ohio, United States Recruiting
Study contacts
- Principal investigator: Jonathan Elliott, MD — Dayton Children's
- Study coordinator: Jonathan Elliott, MD
- Email: elliottj1@childrensdayton.org
- Phone: (812) 582-3059
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Remote electrical neuromodulation to test pain inhibition in migraine and fibromyalgia
We’re testing if the Nerivio wearable can boost the body’s natural pain-inhibition system (CPM) and reduce pain more than a sham device in adults with migraine or fibromyalgia.
-
Elismetrep (K-304) for acute treatment of migraine
This study tests whether a single dose of elismetrep can quickly lessen the pain of a migraine compared with placebo in adults 18 to 75.
-
Magnesium sulfate for acute non-traumatic headache in the ED: 2 g vs 4 g vs standard paracetamol
This study tests whether intravenous magnesium sulfate given in different doses helps adults with acute non-traumatic headache in the emergency department, compared with paracetamol.
-
HEADS Registry: Headache, Ear, Auditory, Dizziness, and Sinus</n> Registry
This registry tests whether collecting online symptom reports from adults in the U.S. with sinus, vestibular, ear, or headache symptoms can help improve diagnosis and treatment.
-
OCT in Neurological Practice: Use of Retinal Layers to Help Diagnose and Follow Neurological Diseases
This study tests whether optical coherence tomography (OCT) of the retina can help in diagnosing and tracking multiple sclerosis, Alzheimer's, Parkinson's, migraines, and other headaches compared with healthy people.
-
Online Hatha Yoga Add-On for High-Frequency Episodic Migraine
This trial tests whether a 12-week online Hatha yoga program added to usual migraine treatment can help adults with high-frequency episodic migraine.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.