Comparing intravenous and oral antibiotics for acute infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and efficacy of oral antibiotic regimens compared to standard intravenous antibiotic treatment in patients admitted to the hospital with acute infections such as respiratory tract infections, urinary tract infections, and cellulitis. Participants will be randomly assigned to receive either intravenous antibiotics or tailored oral antibiotics based on microbiological recommendations. The goal is to determine if oral antibiotics can effectively replace intravenous treatment, potentially reducing hospital stays and associated risks. The study is designed as an open-label, prospective, randomized controlled trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Suspected respiratory tract infection, urinary tract infection, or cellulitis by the attending physician
* Planned or initiated intravenous antibiotic treatment

Exclusion Criteria:

* if received more than two doses of intravenous antibiotics;
* systolic blood pressure \<90 mmHg;
* nausea and/or vomiting in more than one short-term instance during the last 2 days;
* suspected significantly reduced gastrointestinal absorption;
* confirmed plasma-lactate \> 2;
* pregnant or nursing;
* unable to give informed consent;
* severe immunodeficiency;
* urgent vital treatment needed.

Where it's running

• Sygehus Sønderjylland
  Aabenraa, Southern Denmark, Denmark Recruiting
• Nordsjællands Hospital
  Copenhagen, Denmark Recruiting
• Esbjerg and Grindsted Sygehus
  Esbjerg, Denmark Recruiting
• Sygehus Lillebælt
  Kolding, Denmark Recruiting
• Bispebjerg and Frederiksberg Hospital
  Copenhagen, Denmark Active not recruiting
• Herlev and Gentofte Hospital
  Herlev, Denmark Active not recruiting

Study contacts

• Study coordinator: Mariana Bichuette Cartuliares
• Email: mbc@rsyd.dk
• Phone: +45 79971113

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.