Comparing immediate and delayed dental implant placement
Alveolar Ridge Preservation With Immediate or Late Implant Placement: a Multicenter Randomized Controlled Trial
This study is testing whether placing a dental implant right after a tooth is removed works better than waiting a bit, to see if it affects the need for extra treatment later on.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Ghent Academic / other |
| Locations | 2 sites (Ghent, Oost-Vlaanderen and 1 other locations) |
| Trial ID | NCT04741607 on ClinicalTrials.gov |
What this trial studies
This multicenter randomized controlled trial invites patients needing a single dental implant in the premaxilla to participate. Participants will undergo a cone beam computed tomography (CBCT) scan to assess bone integrity before being randomly assigned to either immediate or delayed implant placement after tooth extraction. The study aims to evaluate the need for soft tissue augmentation at 5 months post-procedure by comparing outcomes between the two groups. A total of 60 patients will be treated across 6 centers, with a digital planning process and surgical guide utilized for precision.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a single-rooted tooth in the anterior maxilla that requires extraction and sufficient bone for implant stability.
Not a fit: Patients with systemic diseases, smoking habits, untreated periodontal disease, or untreated caries lesions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into optimal timing for dental implant placement, potentially improving patient outcomes and reducing the need for additional procedures.
How similar studies have performed: Previous studies have shown varying success with immediate implant placement, but this specific approach comparing immediate versus delayed placement in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * at least 18 years old * good oral hygiene defined as full-mouth plaque score ≤ 25% (O'Leary et al. 1972) * presence of a single-rooted tooth in the anterior maxilla (15-25) that needs to be extracted for any reason with at least one neighboring tooth present * at least 3 mm bone available at the apical or palatal aspect of the alveolus to ensure primary implant stability * intact or nearly intact buccal bone wall at the time of extraction (max 3 mm bone missing = max 6 mm distance from free gingival margin to buccal bone crest) Exclusion Criteria: * systemic diseases * smoking * untreated periodontal disease * untreated caries lesions
Where this trial is running
Ghent, Oost-Vlaanderen and 1 other locations
- Ghent University — Ghent, Oost-Vlaanderen, Belgium (Recruiting)
- UCL St Luc — Liège, Belgium (Recruiting)
Study contacts
- Study coordinator: Jan Cosyn, Professor
- Email: jan.cosyn@ugent.be
- Phone: +3293324000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.