Comparing hysteroscopy and aspiration for managing retained tissue after miscarriage
Official title: Hysteroscopy Versus Endouterine Aspiration in the Management of Trophoblastic Retention: A Prospective Randomized Multicenter Study
Run by University Hospital, Montpellier · NCT05789940 · Data updated 2026-11-12
This study tests which method, hysteroscopy or aspiration, works better to remove leftover tissue after a miscarriage and helps women feel better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 42 Years |
| Sex | Women only |
| Enrollment | 220 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 4 sites (Bordeaux and 3 other locations) |
| Status | Recruiting |
| Started | September 18, 2023 |
| Main results expected | September 18, 2027 |
| Study ends | September 18, 2029 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT05789940 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women under 14 weeks of pregnancy who have experienced a spontaneous miscarriage and have been diagnosed with intrauterine trophoblastic retention.
✕Probably not a fit
Patients with known uterine malformations, those who have had previous surgical treatment for intrauterine retention, or those with specific contraindications will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of two surgical techniques, hysteroscopy and endo-uterine aspiration, in managing trophoblastic retention following early miscarriage. The study will assess outcomes at six weeks post-surgery using endovaginal ultrasound to determine which method is more effective in clearing retained tissue. Additionally, it will compare complication rates and the need for further surgical interventions between the two approaches. The trial is designed to provide clearer guidance for clinicians and patients in choosing the appropriate management strategy.
Why it matters
Potential benefit: If successful, this study could lead to improved management options for women experiencing incomplete miscarriages, reducing complications and psychological distress.
How similar studies have gone: While there is limited direct comparison data, previous studies have shown varying success with both hysteroscopy and aspiration techniques in similar contexts, indicating the need for this head-to-head evaluation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Management for trophoblastic retention after early spontaneous miscarriage (\<14 weeks of amenorrhea) * Diagnosis of intrauterine trophoblastic retention by endovaginal pelvic ultrasound * Shared decision for surgical management Exclusion Criteria: * Known uterine malformation * Patient who has received surgical treatment for current intrauterine retention * Patient with an intrauterine device (IUD) * Pregnancy obtained by medically assisted procreation * Indication for emergency surgical management for haemostatic purposes * Failure to obtain free, informed and written consent after a period of reflection * Person not affiliated or beneficiary of a national health insurance system * Person protected by law, under guardianship or curatorship * Person participating in other interventional research involving the human person
Where it's running
-
CHU de Bordeaux - Hôpital Pellegrin
Bordeaux, France Recruiting -
CHU de Montpellier - Hôpital Arnaud de Villeneuve
Montpellier, France Recruiting -
CHU de Nice - Hôpital Archet II
Nice, France Recruiting -
CHU de Nîmes - Hôpital Carémeau
Nîmes, France Recruiting
Study contacts
- Study coordinator: Martha DURAES, MD
- Email: m-duraes@chu-montpellier.fr
- Phone: +334 67 33 65 32
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Letrozole before misoprostol to help pass a missed or anembryonic miscarriage
This will test whether taking letrozole before misoprostol helps people with a missed or anembryonic miscarriage pass the pregnancy more effectively.
-
Walk With Me for Perinatal Grief
A mobile app-based program (Along With Me) with or without a Peer Guide is tested to see if it lowers posttraumatic stress and suicidal thoughts in bereaved parents after pregnancy or early infant loss.
-
Evaluating conservative management for retained products of conception and enhanced myometrial vascularity
This study is testing if gentle treatments for people with leftover pregnancy tissue after a miscarriage can help them recover naturally over two menstrual cycles.
-
Exploring the link between periodontal disease and repeated miscarriages
This study is trying to see if there’s a connection between gum disease and women who have had multiple miscarriages.
-
Exploring the link between decreased ovarian reserve and early miscarriages
This study is trying to see if having a lower number of healthy eggs is linked to early miscarriages in women, to help improve fertility treatments.
-
Using prednisolone to help women with unexplained recurrent miscarriages
This study is testing if taking prednisolone can help women who have had multiple unexplained miscarriages have a successful pregnancy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.