Comparing glucose monitoring methods for diagnosing gestational diabetes
Official title: Insights Into Glucose Variability Using Continuous Glucose Monitoring in Mothers With Gestational Diabetes Compared to Mothers at High Risk of Gestational Diabetes Who Have a Negative Oral Glucose Tolerance Test.
Run by Portsmouth Hospitals NHS Trust · NCT05981547 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if continuous glucose monitoring can better diagnose gestational diabetes in pregnant women compared to the standard glucose tolerance test.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 400 (estimated) |
| Sponsor | Portsmouth Hospitals NHS Trust Government |
| Locations | 1 site (Portsmouth) |
| Trial ID | NCT05981547 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant women aged 18 and above, between 12-26 weeks gestation, identified as having one or more risk factors for GDM.
✕Probably not a fit
Patients with pre-existing diabetes or those who have previously had GDM may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to compare glucose variability in pregnant women diagnosed with gestational diabetes (GDM) against those at high risk but not diagnosed. Utilizing continuous glucose monitoring (CGM) sensors, the study will involve 400 participants around the time of their standard GDM testing. A subgroup of 60 participants will be monitored further to assess the progression of high blood glucose levels. The goal is to evaluate the reliability of CGM as a diagnostic tool compared to the traditional oral glucose tolerance test (OGTT).
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of gestational diabetes, potentially reducing complications for mothers and babies.
How similar studies have gone: While the use of CGM in managing diabetes is well-established, this approach for diagnosing GDM is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female aged 18 years of above * Between 12-26 weeks gestation * Identified by NICE as having one or more independent risk factor for GDM * Suitable for the standard care pathway under the joint antenatal clinic for GDM * Willing and able to give informed consent. Exclusion Criteria: * Pre-existing diabetes * Previous GDM * Unsuitable for standard joint antenatal clinic pathway * Known allergy to freestyle libre adhesive pad * Planning to move geographical area during the study timeframe * Participating in a different study that could interfere with glucose levels or affect ability to participate.
Where it's running
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Portsmouth Hospitals University NHS Trust
Portsmouth, United Kingdom Recruiting
Study contacts
- Study coordinator: Michael Cummings, MBBS
- Email: michael.cummings@porthosp.nhs.uk
- Phone: 02392286044
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Early Glucose Patterns in Pregnant Women at Risk for GDM
This study tests whether continuous glucose monitoring in early pregnancy can detect dysglycemia before GDM is diagnosed, in women with and without known risk factors.
-
Probiotic-augmented therapy for gestational diabetes
This trial tests whether adding multistrain probiotics to metformin, insulin, or their combination can improve blood sugar control and inflammation in pregnant women with gestational diabetes.
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Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes
This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.
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How sleep, lifestyle, and metabolism relate to pregnancy outcomes in gestational diabetes
This project will see if sleep quality, anxiety, eating and activity habits, and metabolic markers relate to blood sugar control and birth outcomes in pregnant people with gestational diabetes.
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Pre-eclampsia risk in pregnancies after oocyte donation
We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.
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Mobile-based obstetric monitoring for hypertension and diabetes during pregnancy
A mobile app-based program lets pregnant people with high blood pressure or gestational diabetes track BP and glucose at home and share results with their care team to guide care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.