Comparing flapless and flap surgery techniques for dental implants

Width of Keratinazed Mucosa in Immediately Loaded Posterior Implant Restorations Treated With Different Surgical Approaches: Randomized Clinical Study.

Not applicable Interventional University of Milan · NCT05073952

This study tests whether using a flapless technique or traditional flap surgery for dental implants leads to better healing of the gum tissue in patients with missing back teeth.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment44 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Milan Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Milan, MI)
Trial IDNCT05073952 on ClinicalTrials.gov

What this trial studies

This study evaluates the differences in keratinized mucosa after dental implant placement using two techniques: a flapless approach and traditional flap surgery with connective tissue grafts. It focuses on patients with partial edentulism in the posterior region who have sufficient bone volume for implant placement. The study utilizes computer-guided implantology to enhance precision and outcomes. Participants will be monitored for variations in keratinized mucosa following the procedures.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with partial edentulism in the posterior region and adequate bone volume for implant placement.

Not a fit: Patients with systemic conditions that affect healing or those who cannot maintain proper oral hygiene may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved healing and aesthetic outcomes for patients receiving dental implants.

How similar studies have performed: Previous studies have shown promising results with flapless implant techniques, suggesting potential benefits in terms of recovery and mucosal health.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18+
* Patients with partial edentulism in the posterior region (4-7) upper or lower for at least 3 months
* Patient whose tomographic examination shows adequate bone volumes for computer guided placement of a standard diameter implant (\> 3.5 mm) without the need for bone regeneration procedures
* Patients who have accepted informed consent and participation in the study
* Patients who do not have exclusion criteria

Eclusion Criteria

* Patients who refuse to co-operate
* Systemic conditions of exclusion:

  * Medical conditions requiring prolonged use of steroids
  * Severe hemophilia
  * In therapy with intravenous bisphosphonates
  * History of white blood cell dysfunction or deficiency
  * History of head and neck radiotherapy or chemotherapy
  * History of kidney failure
  * Pregnant or breastfeeding patient
  * History of uncontrolled endocrine disorders
  * Physical handicaps that hinder proper oral hygiene
  * Use of experimental devices or drugs within 30 days prior to implant placement surgery
  * Alcoholism or drug abuse
  * Smokers of\> 10 cigarettes per day or the equivalent cigar or\> 10 tobacco-based chewings per day
  * Conditions or circumstances that prevent the completion of participation in the study or interfere with the analysis of the study results

Local exclusion conditions:

* Local inflammation, including untreated periodontitis
* Patients with erosive lichen planus
* History of local radiation therapy
* Presence of bone lesions
* Unhealed extraction sites
* History of bone reconstruction and bone grafting techniques in the sites where the implants are to be inserted
* Bruxism
* Bleeding index\> 30% and number of pockets\> 5mm greater than 10

Where this trial is running

Milan, MI

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Variation of Keratinized Mucosa After Implant Surgerydental implantKeratinized mucosaConnective tissue graftflapless implant placementComputer guided implantologyImmediate loading
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.