Comparing fixed and removable twin blocks for treating jaw growth issues in children

Effects of Modified Fixed Twin Block Versus Removable Twin Block on Skeletal Class 2 Growing Patients With Mandibular Deficiency

Not applicable Interventional Cairo University · NCT05993156

This study tests whether a new fixed jaw appliance works better than a removable one for helping children with jaw growth issues.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment24 (estimated)
Ages9 Years to 15 Years
SexFemale
SponsorCairo University Academic / other
Locations1 site (Cairo)
Trial IDNCT05993156 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effects of a modified fixed twin block appliance compared to a conventional removable twin block appliance in growing patients with skeletal Class 2 malocclusion and mandibular deficiency. The study aims to determine if there are significant differences in treatment outcomes, including overjet reduction and other dentoskeletal effects. It employs a randomized parallel group design with a 1:1 allocation ratio to ensure unbiased results. Primary and secondary outcomes will be assessed to gauge the effectiveness and patient acceptance of each appliance type.

Who should consider this trial

Good fit: Ideal candidates are growing patients diagnosed with skeletal Class 2 malocclusion and a mandibular deficiency.

Not a fit: Patients who are skeletally mature, have normal mandibles with only protruded upper incisors, or have dental anomalies may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into more effective orthodontic treatments for children with jaw growth issues.

How similar studies have performed: While similar studies have explored the effectiveness of twin block appliances, this specific comparison of modified fixed versus removable types is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Skeletal Class 2 malocclusion cases (ANB ≥ 5 degrees)
* Overjet ≥ 5 mm
* Growing patients (CVMS 3 or 4)

Exclusion Criteria:

* Skeletally mature patients 15 years old or above
* Patients with normal mandible and only protruded upper incisors.
* Syndromic, cleft patients and patients with dental anomalies
* Previous orthopaedic or orthodontic treatment
* No sex predilection.

Where this trial is running

Cairo

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions MalocclusionAngle Class IIMandible Smallorthodonticsorthopedicsmyofunctional applianceTwinblock
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.