Clinical trial Recruiting at 1 site Observational Ages 18 and up

Comparing five advanced treatments for axial spondyloarthritis and psoriatic arthritis

Official title: Clinical Characteristics, Treatment Patterns and Outcomes in Patients With axSpA and PsA Following Initiation of Bimekizumab, Risankizumab, Guselkumab, Upadacitinib or a TNF Inhibitor

Run by Adelphi Real World · NCT07166315 · Data updated 2026-11-12

This project will see how well bimekizumab, risankizumab, guselkumab, upadacitinib, or a TNF inhibitor work for adults with axSpA or PsA who have just started one of these medicines, using medical records and patient surveys.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment700 (estimated)
SponsorAdelphi Real World
Industry-sponsored
Drugs / interventionsbimekizumab, risankizumab, guselkumab, adalimumab, upadacitinib
Locations1 site (Bath, Somerset)
StatusRecruiting
StartedJuly 7, 2025
Main results expectedJuly 31, 2027
Study endsJuly 31, 2027
Registry record updatedOctober 27, 2026
Trial IDNCT07166315 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older with a clinical diagnosis of axSpA or PsA who started one of the listed advanced therapies within one month before enrollment and are not enrolled in another clinical trial.

Probably not a fit

Patients already taking the treatment for longer than one month before enrollment, those currently enrolled in another clinical trial, or those unable or unwilling to complete surveys are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will follow adults with axial spondyloarthritis or psoriatic arthritis who have begun treatment with one of five advanced therapies at participating NHS hospitals in the United Kingdom. Patients will complete surveys about symptoms, quality of life, and treatment experience during the study period. Investigators will also review participants' medical records retrospectively toward the end of follow-up to capture clinical outcomes, medication history, and healthcare use. The design is intended to provide real-world comparisons of effectiveness and patient-reported experience across these therapies.

Why it matters

Potential benefit: If successful, the findings could help patients and clinicians choose treatments that work better in everyday practice and better reflect patient experiences.

How similar studies have gone: Registries and observational studies have produced useful real-world effectiveness and safety data for TNF inhibitors and JAK inhibitors, while comparable real-world comparisons including newer agents like bimekizumab and some IL-23 inhibitors remain relatively limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participant has a clinical diagnosis of axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA).
* Participant has been prescribed advanced therapy within one month prior to enrolment in the study, to treat their axSpA or PsA.
* Participant is aged 18 years or older at enrolment.

Exclusion Criteria:

-Participation in a clinical trial at enrolment.

Where it's running

  • Royal National Hospital for Rheumatic Diseases
    Bath, Somerset, United Kingdom
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.