Comparing fentanyl and dexmedetomidine for pain relief after knee surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of fentanyl versus dexmedetomidine as an adjunct to bupivacaine in providing postoperative analgesia following total knee arthroplasty. It will measure the total amount of rescue analgesic used in the first 48 hours post-surgery, assess pain scores at various time points, and evaluate patient satisfaction with the analgesia provided. Additionally, the study will monitor for any adverse events and the length of hospital stay associated with each treatment group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1 - Patient acceptance 2. Cooperative patients 3. Age: ≥21 and 85\< years' old 4. Sex: both sexes (males or females). 5. Physical status: ASA Ι \& II\& Ш. 6. Body Mass Index (BMI): ≤ 35 kg/m2. 7. Type of operation: elective unilateral knee surgeries (TKA, ACL, knee arthroscopy)

Exclusion Criteria:

. Patient with any contraindications of regional blocks (as coagulopathy or local infection at injection site) 2. Patients with known history of allergy to the study drugs (bupivacaine, dexmedetomidine and fentanyl).

3\. Advanced hepatic, renal, cardiovascular, neurologic and respiratory diseases.

4.Chronic opioid use (more than 3 months or daily oral morphine \> 5 mg /day for 1 month)

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Where it's running

• faculty of human medicine, Zagazig university hospitals
  El Sharkia, Egypt Recruiting

Study contacts

• Study coordinator: Dina Sadek Salem, MD
• Email: sherifelagamy@yahoo.com
• Phone: 01099333513

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.