Comparing fentanyl and dexmedetomidine for pain relief after knee surgery
Analgesic Effect of Fentanyl Vs Dexmedetomidine As Adjuvant to Bupivacaine in Combined IPACK and Adductor Canal Block After Knee Surgeries
This study is testing whether fentanyl or dexmedetomidine works better for pain relief after knee surgery to see which one helps patients feel more comfortable and satisfied.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 111 (estimated) |
| Ages | 21 Years to 85 Years |
| Sex | All |
| Sponsor | Zagazig University Government |
| Locations | 1 site (El Sharkia) |
| Trial ID | NCT06759116 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of fentanyl versus dexmedetomidine as an adjunct to bupivacaine in providing postoperative analgesia following total knee arthroplasty. It will measure the total amount of rescue analgesic used in the first 48 hours post-surgery, assess pain scores at various time points, and evaluate patient satisfaction with the analgesia provided. Additionally, the study will monitor for any adverse events and the length of hospital stay associated with each treatment group.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 to 85 undergoing elective unilateral knee surgeries with a physical status classified as ASA I, II, or III.
Not a fit: Patients with contraindications to regional blocks, chronic opioid use, or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance postoperative pain management strategies for patients undergoing knee surgeries.
How similar studies have performed: Previous studies have shown promising results in using adjuvants like dexmedetomidine and fentanyl for postoperative analgesia, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1 - Patient acceptance 2. Cooperative patients 3. Age: ≥21 and 85\< years' old 4. Sex: both sexes (males or females). 5. Physical status: ASA Ι \& II\& Ш. 6. Body Mass Index (BMI): ≤ 35 kg/m2. 7. Type of operation: elective unilateral knee surgeries (TKA, ACL, knee arthroscopy) Exclusion Criteria: . Patient with any contraindications of regional blocks (as coagulopathy or local infection at injection site) 2. Patients with known history of allergy to the study drugs (bupivacaine, dexmedetomidine and fentanyl). 3\. Advanced hepatic, renal, cardiovascular, neurologic and respiratory diseases. 4.Chronic opioid use (more than 3 months or daily oral morphine \> 5 mg /day for 1 month) \-
Where this trial is running
El Sharkia
- faculty of human medicine, Zagazig university hospitals — El Sharkia, Egypt (Recruiting)
Study contacts
- Study coordinator: Dina Sadek Salem, MD
- Email: sherifelagamy@yahoo.com
- Phone: 01099333513
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.