Comparing eye fluid proteins in glaucoma patients and healthy individuals
Comparative Analysis of Aqueous Humor Adipokines in Patients With Glaucoma and Healthy Controls
This study is testing the differences in certain proteins found in the eye fluid of people with glaucoma and healthy individuals to better understand how these proteins might relate to the disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Peking University Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06190119 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the differences in adipokines present in the aqueous humor of patients diagnosed with primary open-angle glaucoma (POAG) compared to healthy controls who have undergone cataract surgery. The study will include adults aged 18 and older, focusing on the potential role of these proteins in neuroinflammation associated with glaucoma. By analyzing the aqueous humor, researchers hope to gain insights into the underlying mechanisms of glaucoma and its relationship with adipokines.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with a diagnosis of primary open-angle glaucoma.
Not a fit: Patients with other ocular diseases, systemic diseases, or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of glaucoma and lead to improved diagnostic and therapeutic strategies.
How similar studies have performed: While the specific approach of comparing adipokines in aqueous humor is novel, similar studies have explored the role of inflammatory markers in glaucoma with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery). Exclusion Criteria: * Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded. * Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery. * History of Ocular Trauma or Inflammation * Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded. * Pregnancy or Lactation: Females who are pregnant or lactating are excluded. * Presence of any retinal or optic nerve disease other than glaucoma.
Where this trial is running
Beijing, Beijing
- Peking University Third Hosipital — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Chun Zhang, Ph.D. — Peking University Third Hospital
- Study coordinator: Ziyao Xia, M.D.
- Email: emilyhsia@163.com
- Phone: +8618810838416
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.