Comparing digital and speculum exams for preterm prelabor rupture of membranes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of two different examination methods—digital exams and speculum exams—on the latency of pregnancy in patients diagnosed with preterm prelabor rupture of membranes (PPROM). Patients between 22 and 33 weeks of gestation who have confirmed PPROM will be randomly assigned to receive either type of exam to determine if one method is superior in prolonging the time before delivery. The study aims to address concerns regarding the impact of these exams on pregnancy outcomes and to provide evidence-based recommendations for clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 22 weeks 0 days gestation to 33 weeks 5 days gestation
* Clinical or laboratory confirmation of PPROM
* At least 8 hours after rupture event
* English speaking

Notably, for patients \<25 weeks, approach for enrollment will be deferred until after the patient has discussed their desires for fetal resuscitation with the care team and are at a gestational age where they would desire this resuscitation.

Exclusion Criteria:

* Contraindications to digital examination
* COVID-19 positive on admission

Where it's running

• Barnes Jewish Hospital
  St Louis, Missouri, United States Recruiting

Study contacts

• Study coordinator: Nandini Raghuraman, MD
• Email: nraghuraman@wustl.edu
• Phone: 3142732939

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Extended azithromycin treatment in prelabor rupture of membranes at periviable gestations

  This study tests whether giving extra doses of azithromycin beyond the standard antibiotics can improve outcomes for pregnant people with PPROM between 22 and 28 weeks.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07669207

• Emotional Freedom Technique and Music Therapy in High-Risk Pregnancy for PPROM

  This study tests whether emotional freedom techniques and music therapy can help pregnant women with PPROM or PROM cope better and feel less stress.

  Recruiting Selcuk University · Konya, Konya · NCT07559071

• Tailored IL-6–guided antibiotic and steroid treatment to delay birth after PPROM

  This tests whether using an IL-6 lab result from amniotic fluid to guide antibiotics and steroids can help people with PPROM stay pregnant longer and improve outcomes for parent and baby.

  Recruiting at 3 sites Phase 3 The Central and Eastern European Gynecologic Oncology Group · Brno and 2 other locations · NCT07107477

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.