Comparing different methods of providing breathing support to premature newborns
Comparing Intubation Rates in the Delivery Room by Interface
This study is testing different ways to help premature newborns breathe better right after birth to see which method reduces the need for more invasive breathing support.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 42 (estimated) |
| Ages | 0 Weeks to 30 Weeks |
| Sex | All |
| Sponsor | University of Illinois College of Medicine at Peoria Academic / other |
| Locations | 1 site (Peoria, Illinois) |
| Trial ID | NCT05609773 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of various non-invasive interfaces for positive pressure ventilation (PPV) in premature neonates born at less than 30 weeks gestation. It will compare the intubation rates associated with different resuscitation methods, including face masks, nasal tubes, and nasal prongs, to determine which method minimizes the need for invasive ventilation and reduces complications such as bronchopulmonary dysplasia. The study will be conducted at the University of Illinois College of Medicine in Peoria, Illinois, focusing on infants who require resuscitation at birth.
Who should consider this trial
Good fit: Ideal candidates for this study are premature infants born at less than 30 weeks gestation who require resuscitation at birth.
Not a fit: Patients who may not benefit from this study include those with congenital diaphragmatic hernia or those who do not require positive pressure ventilation due to major congenital anomalies.
Why it matters
Potential benefit: If successful, this study could lead to improved respiratory support methods for premature infants, reducing the need for intubation and associated complications.
How similar studies have performed: Previous studies have indicated that bi-nasal prongs may lead to lower intubation rates, suggesting that this approach has shown promise in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: All resuscitated infants \< 30 weeks' gestation born at OSF SFMC Exclusion Criteria: Diagnosis of congenital diaphragmatic hernia No PPV needed, or no resuscitation desired due to major congenital anomalies or peri- viable status
Where this trial is running
Peoria, Illinois
- University of Illinois College of Medicince — Peoria, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Ashley Fischer, MD — University of Illinois College of Medicine at Peoria
- Study coordinator: Ashley Fischer, MD
- Email: Ashley.M.Fischer2@osfhealthcare.org
- Phone: 309-624-8977
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.