Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

Comparing different methods for central venous access in difficult patients

Official title: Central Venous Access in Patients With Difficult Cannulation, A Randomized Controlled Trial

Run by Hospital Civil de Guadalajara · NCT04265703 · Data updated 2026-11-12

This study tests which method of placing a central venous catheter works best and is safest for patients who have difficult veins due to certain health conditions.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment315 (estimated)
SponsorHospital Civil de Guadalajara
Academic / other
Locations1 site (Guadalajara)
StatusRecruiting
StartedFebruary 27, 2024
Main results expectedFebruary 28, 2027
Study endsFebruary 28, 2027
Registry record updatedMarch 12, 2026
Trial IDNCT04265703 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients requiring central venous catheterization who exhibit respirophasic variation in the cross-sectional area of their jugular veins.

Probably not a fit

Patients under 18 years old or those with previous failed attempts at non-ultrasound guided techniques may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness and safety of ultrasound-guided central venous catheterization at three different sites: the internal jugular vein, subclavian vein, and innominate vein. It addresses the challenges faced by critical care physicians when attempting to cannulate patients with specific conditions that complicate traditional methods. By comparing these approaches, the study seeks to identify the most successful technique for patients with respirophasic variation in vein size. The trial will be conducted in multiple centers to gather a diverse patient population.

Why it matters

Potential benefit: If successful, this study could improve the success rate and safety of central venous access in critically ill patients.

How similar studies have gone: Previous studies have shown high success rates for ultrasound-guided cannulation, but this specific comparison of sites is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who need central venous catheterization, and have respirophasic variation in cross-sectional area of jugular veins

Exclusion Criteria:

* Less than 18 years-old

  * Patients with previous failed attempts with non-ultrasound guided technique
  * Non-resolved pneumothorax/hemothorax at enrollment
  * Refusal to sign informed consent

Where it's running

  • Hospital Civil Fray Antonio Alcalde
    Guadalajara, Mexico
    Recruiting

Study contacts

  • Principal investigator: Miguel Ibarra-Estrada, MD — Hospital Civil Fray Antonio Alcalde
  • Study coordinator: Miguel Ibarra-Estrada, MD
  • Email: drmiguelibarra@hotmail.com
  • Phone: 3317593502

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.