Comparing different methods for central venous access in difficult patients
Official title: Central Venous Access in Patients With Difficult Cannulation, A Randomized Controlled Trial
Run by Hospital Civil de Guadalajara · NCT04265703 · Data updated 2026-11-12
This study tests which method of placing a central venous catheter works best and is safest for patients who have difficult veins due to certain health conditions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 315 (estimated) |
| Sponsor | Hospital Civil de Guadalajara Academic / other |
| Locations | 1 site (Guadalajara) |
| Status | Recruiting |
| Started | February 27, 2024 |
| Main results expected | February 28, 2027 |
| Study ends | February 28, 2027 |
| Registry record updated | March 12, 2026 |
| Trial ID | NCT04265703 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients requiring central venous catheterization who exhibit respirophasic variation in the cross-sectional area of their jugular veins.
✕Probably not a fit
Patients under 18 years old or those with previous failed attempts at non-ultrasound guided techniques may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness and safety of ultrasound-guided central venous catheterization at three different sites: the internal jugular vein, subclavian vein, and innominate vein. It addresses the challenges faced by critical care physicians when attempting to cannulate patients with specific conditions that complicate traditional methods. By comparing these approaches, the study seeks to identify the most successful technique for patients with respirophasic variation in vein size. The trial will be conducted in multiple centers to gather a diverse patient population.
Why it matters
Potential benefit: If successful, this study could improve the success rate and safety of central venous access in critically ill patients.
How similar studies have gone: Previous studies have shown high success rates for ultrasound-guided cannulation, but this specific comparison of sites is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who need central venous catheterization, and have respirophasic variation in cross-sectional area of jugular veins Exclusion Criteria: * Less than 18 years-old * Patients with previous failed attempts with non-ultrasound guided technique * Non-resolved pneumothorax/hemothorax at enrollment * Refusal to sign informed consent
Where it's running
-
Hospital Civil Fray Antonio Alcalde
Guadalajara, Mexico Recruiting
Study contacts
- Principal investigator: Miguel Ibarra-Estrada, MD — Hospital Civil Fray Antonio Alcalde
- Study coordinator: Miguel Ibarra-Estrada, MD
- Email: drmiguelibarra@hotmail.com
- Phone: 3317593502
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.