Comparing different methods for central venous access in difficult patients

Central Venous Access in Patients With Difficult Cannulation, A Randomized Controlled Trial

Not applicable Interventional Hospital Civil de Guadalajara · NCT04265703

This study tests which method of placing a central venous catheter works best and is safest for patients who have difficult veins due to certain health conditions.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment315 (estimated)
Ages18 Years to 80 Years
SexAll
SponsorHospital Civil de Guadalajara Academic / other
Locations1 site (Guadalajara)
Trial IDNCT04265703 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness and safety of ultrasound-guided central venous catheterization at three different sites: the internal jugular vein, subclavian vein, and innominate vein. It addresses the challenges faced by critical care physicians when attempting to cannulate patients with specific conditions that complicate traditional methods. By comparing these approaches, the study seeks to identify the most successful technique for patients with respirophasic variation in vein size. The trial will be conducted in multiple centers to gather a diverse patient population.

Who should consider this trial

Good fit: Ideal candidates are patients requiring central venous catheterization who exhibit respirophasic variation in the cross-sectional area of their jugular veins.

Not a fit: Patients under 18 years old or those with previous failed attempts at non-ultrasound guided techniques may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the success rate and safety of central venous access in critically ill patients.

How similar studies have performed: Previous studies have shown high success rates for ultrasound-guided cannulation, but this specific comparison of sites is novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who need central venous catheterization, and have respirophasic variation in cross-sectional area of jugular veins

Exclusion Criteria:

* Less than 18 years-old

  * Patients with previous failed attempts with non-ultrasound guided technique
  * Non-resolved pneumothorax/hemothorax at enrollment
  * Refusal to sign informed consent

Where this trial is running

Guadalajara

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Critical IllnessCentral venous accessUltrasound-guided catheterizationInnominate veinBrachiocephalic vein
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.