Comparing different insulin dilutions for treating high blood sugar in critically ill patients

A Comparative Study of Efficacy and Safety Between Different Dilution of Insulin Infusion in Controlling Blood Sugar Level in ICU Patient

This study tests different strengths of insulin to see which one works best for managing high blood sugar in critically ill patients in the ICU.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 74 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Universiti Sains Malaysia (other)
• Locations: 1 site (Kota Bharu, Kelantan)
• Trial ID: NCT06180824 on ClinicalTrials.gov

What this trial studies

This study investigates the efficacy and safety of various dilutions of insulin in managing hyperglycemia in critically ill patients. It focuses on patients admitted to the ICU with elevated blood sugar levels, aiming to determine the optimal insulin dilution that minimizes complications associated with hyperglycemia. The study will assess the impact of insulin adsorption on infusion equipment and its effect on glucose control. By evaluating these factors, the research seeks to improve glycemic management in a critical care setting.

Who should consider this trial

Good fit: Ideal candidates are adult patients aged 18 and above, admitted to the ICU with high blood sugar levels within 12 hours of admission.

Not a fit: Patients who are pregnant, have a history of allergic reactions to gelafundin, or are in cardiogenic shock may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved blood sugar control and reduced complications for critically ill patients.

How similar studies have performed: While there is limited data from controlled trials on this specific approach, the importance of glycemic control in critically ill patients has been recognized in other studies.

Eligibility criteria

Inclusion Criteria:

1. Patient admitted to ICU Hospital USM regardless of whether patient intubated or not.
2. Adult patient 18 years old and above.
3. 2 consecutive blood sugar more than 10 mmol/L including patient with diabetic ketoacidosis and hyperosmolar hyperglycaemic state.
4. Within 12 hours from admission.
5. Patient not in high inotropic support and with APACHE II score less than 17.

Exclusion Criteria:

1. Pregnancy.
2. History of any allergic from previous gelafundin infusion or known patient to have allergic towards gelafundin (allergic card, or information from relatives)
3. Post cardiac arrest or prolonged resuscitation.
4. Patient with cardiogenic shock.

Where this trial is running

Kota Bharu, Kelantan

• Mohd Zulfakar Mazlan — Kota Bharu, Kelantan, Malaysia (RECRUITING)

Conditions: Hyperglycemia, insulin, hyperglycemia, diluent, plastic syringe