Comparing Dexamethasone and Dexmedetomidine for Pain Relief After Knee Surgery
Dexamethasone Vs. Dexmedetomidine for ESPB in Pain Management After Total Knee Arthroplasty
PHASE4 · Poznan University of Medical Sciences · NCT06470100
This study is testing whether adding Dexamethasone or Dexmedetomidine to local anesthetics can help people feel less pain and recover faster after knee surgery.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Poznan University of Medical Sciences (other) |
| Locations | 1 site (Poznan, Poznań) |
| Trial ID | NCT06470100 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of perineural Dexamethasone and Dexmedetomidine on the duration of erector spinal plane blocks in patients undergoing knee arthroplasty. It aims to enhance postoperative pain management by comparing these two adjuvants to local anesthetics. The research addresses a gap in existing literature regarding their effectiveness specifically in knee surgeries. The goal is to identify which adjuvant provides better pain relief and facilitates faster recovery after surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 100 years undergoing primary hip arthroplasty with ASA physical status 1, 2, or 3.
Not a fit: Patients with severe comorbidities, such as ASA physical status 4 or 5, or those with a history of opioid abuse may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing knee arthroplasty.
How similar studies have performed: While there is considerable research on dexamethasone and dexmedetomidine in orthopedic surgeries, this specific approach in knee surgery is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients undergoing primary hip arthroplasty * aged \>18 years and \<100 years * ASA physical status 1, 2 or 3. Exclusion Criteria: * if they refused to participate, * had a history of opioid abuse, * had an infection of the site of needle puncture, * were less than 18 years of age, * were postponed as having ASA 4 or 5, * had an allergy to any of the drugs used in the study, * renal failure (estimated glomerular filtration rate \<15ml/min/1.73m2), * liver failure, * known or suspected coagulopathy, * pre-existing anatomical or neurological disorders in the lower extremities, * intellectual disability with problems in pain evaluation, * severe psychiatric illness.
Where this trial is running
Poznan, Poznań
- Poznan University of Medical Sciences — Poznan, Poznań, Poland (RECRUITING)
Study contacts
- Study coordinator: Malgorzata Domagalska, M.D. Ph.D.
- Email: mdomagalska@ump.edu.pl
- Phone: +48 61 8738327
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Knee Osteoarthritis, Knee Arthritis, Knee Disease, Knee Pain Chronic