Comparing Dexamethasone Administration Routes and Anesthetic Concentrations in Scoliosis Surgery for Children
The Effect of Dexamethasone Administration Route and Local Anesthetic Concentration on Pain, Inflammatory Response, and Neuromonitoring in Children Undergoing Scoliosis Correction
This study is testing whether giving dexamethasone in different ways and using different amounts of local anesthetics can help reduce pain and inflammation for kids having scoliosis surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 10 Years to 18 Years |
| Sex | All |
| Sponsor | Poznan University of Medical Sciences Academic / other |
| Locations | 1 site (Poznan) |
| Trial ID | NCT06789029 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of different routes of dexamethasone administration (intravenous vs. perineural) and varying concentrations of local anesthetics on postoperative pain, inflammatory response, and neuromonitoring in children undergoing scoliosis correction surgery. The research aims to enhance pain management and minimize inflammation, which are critical for improving recovery outcomes. By analyzing parameters such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), the study seeks to provide insights that could refine regional anesthesia protocols and improve patient safety during complex surgical procedures.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 10 to 18 years scheduled for idiopathic scoliosis surgery.
Not a fit: Patients with infections at the site of the regional block, coagulation disorders, or those on regular steroid medication may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management and reduced inflammatory responses in children undergoing scoliosis surgery.
How similar studies have performed: While the use of dexamethasone in regional anesthesia is established, this specific comparison of administration routes and concentrations is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>10 and \<18 years old * scheduled for idiopathic scoliosis surgery Exclusion Criteria: * included infection at the site of the regional block, * coagulation disorders, * immunodeficiency, * American Society of Anesthesiologists (ASA) physical status of IV or higher, * history of regular steroid medication.
Where this trial is running
Poznan
- Poznan University of Medical Sciences — Poznan, Poland (Recruiting)
Study contacts
- Study coordinator: Malgorzata Reysner, M.D. Ph.D.
- Email: mdomagalska@ump.edu.pl
- Phone: +48608762068
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.