Comparing corticosteroid injection and nerve hydrodissection for carpal tunnel syndrome
Official title: Comparison of the Efficacy of Corticosteroid Injection and Saline Nerve Hydrodissection on Electrophysiological Study, Pain, Function and Sonographic Findings in the Treatment of Carpal Tunnel Syndrome: A Randomized Controlled Trial
Run by Kirsehir Ahi Evran Universitesi · NCT06882603 · Data updated 2026-11-12
This study is testing whether corticosteroid injections or nerve hydrodissection can help people with carpal tunnel syndrome feel better when combined with exercise therapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Kirsehir Ahi Evran Universitesi Academic / other |
| Locations | 2 sites (Kırşehir, City Centre and 1 other locations) |
| Status | Recruiting |
| Started | October 14, 2025 |
| Main results expected | February 5, 2026 |
| Study ends | May 5, 2026 |
| Registry record updated | December 10, 2025 |
| Trial ID | NCT06882603 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-65 diagnosed with carpal tunnel syndrome who can provide informed consent.
✕Probably not a fit
Patients with conditions such as cervical radiculopathy, systemic diseases, or those who have previously undergone carpal tunnel surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of corticosteroid injections and nerve hydrodissection in treating carpal tunnel syndrome (CTS) by comparing their benefits alongside exercise therapy. Participants diagnosed with CTS will receive either treatment and their symptoms, including pain and numbness, will be monitored. The study seeks to determine which method provides better relief for patients suffering from this common nerve compression condition. The research will involve a thorough assessment of patient responses to the interventions over a specified period.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment options for patients suffering from carpal tunnel syndrome.
How similar studies have gone: Previous studies have shown varying degrees of success with corticosteroid injections for CTS, but the combination with nerve hydrodissection is less commonly tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Female and male patients aged 18-65 who applied to Ahi Evran University Physical Medicine and Rehabilitation Polyclinic and diagnosed with carpal tunnel syndrome through clinical and EMG 2. Patients who can understand the information form correctly and are cooperative 3. Patients who consented to participate in the study according to the informed consent form Exclusion Criteria: 1. Cervical radiculopathy 2. Polyneuropathy 3. Brachial plexopathy 4. Systemic corticosteroid use 5. History of fracture and trauma in the forearm and wrist on the treated side 6- Inflammatory rheumatic disease 7- Pregnant and breastfeeding patients 8- Systemic diseases such as renal failure, peptic ulcer, diabetes, hypothyroidism, coagulation disorders 9- Patients who have undergone carpal tunnel syndrome surgery 10- Thoracic outlet syndrome 11- Thenar atrophy, severe carpal tunnel syndrome 12- Patient is unwilling or states that they cannot participate for any reason
Where it's running
-
Ahi Evran University
Kırşehir, City Centre, Turkey (Türkiye) Recruiting -
Ahi Evran University
Kırşehir, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Basak Cigdem Karacay, Assoc. Prof — Kirsehir Ahi Evran Universitesi
- Study coordinator: Basak Cigdem Karacay, Assoc. Prof.
- Email: basakcigdem@hotmail.com
- Phone: +905445094803
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Ultrasound-Guided Injection for Carpal Tunnel Syndrome: Hyaluronic Acid vs Corticosteroid vs 5% Glucose
This study tests three ultrasound-guided injections (hyaluronic acid, corticosteroid, and 5% glucose) to see which best helps adults with mild to moderate carpal tunnel syndrome.
-
Open vs ultrasound-guided carpal tunnel release ( CTS )
This study compares two surgical approaches for carpal tunnel syndrome to see which helps people recover better after surgery.
-
Amniotic Membrane and Secretome Added to Carpal Tunnel Release
This trial tests whether adding amniotic membrane and secretome to carpal tunnel surgery helps people with moderate-to-severe CTS recover better than surgery alone.
-
Reliability and validity of hand function tests in carpal tunnel syndrome
This study tests whether three hand function tests (JTHFT, MDT, and Nine-Hole Peg Test) are reliable and valid for people with carpal tunnel syndrome.
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Neuromobilization, Tendon Gliding, or Both for Mild to Moderate Carpal Tunnel Syndrome
This trial tests whether neuromobilization, tendon gliding exercises, or a combination of both help reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome.
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MeDe: Carpal tunnel release with added lacertus release vs carpal tunnel release alone
In adults with carpal tunnel syndrome, this trial tests whether adding a lacertus fibrosus release to the standard carpal tunnel release helps reduce symptoms and improve hand function.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.