Clinical trial Recruiting at 2 sites Interventional Ages 18 to 65

Comparing corticosteroid injection and nerve hydrodissection for carpal tunnel syndrome

Official title: Comparison of the Efficacy of Corticosteroid Injection and Saline Nerve Hydrodissection on Electrophysiological Study, Pain, Function and Sonographic Findings in the Treatment of Carpal Tunnel Syndrome: A Randomized Controlled Trial

Run by Kirsehir Ahi Evran Universitesi · NCT06882603 · Data updated 2026-11-12

This study is testing whether corticosteroid injections or nerve hydrodissection can help people with carpal tunnel syndrome feel better when combined with exercise therapy.

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment90 (estimated)
SponsorKirsehir Ahi Evran Universitesi
Academic / other
Locations2 sites (Kırşehir, City Centre and 1 other locations)
StatusRecruiting
StartedOctober 14, 2025
Main results expectedFebruary 5, 2026
Study endsMay 5, 2026
Registry record updatedDecember 10, 2025
Trial IDNCT06882603 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18-65 diagnosed with carpal tunnel syndrome who can provide informed consent.

Probably not a fit

Patients with conditions such as cervical radiculopathy, systemic diseases, or those who have previously undergone carpal tunnel surgery may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of corticosteroid injections and nerve hydrodissection in treating carpal tunnel syndrome (CTS) by comparing their benefits alongside exercise therapy. Participants diagnosed with CTS will receive either treatment and their symptoms, including pain and numbness, will be monitored. The study seeks to determine which method provides better relief for patients suffering from this common nerve compression condition. The research will involve a thorough assessment of patient responses to the interventions over a specified period.

Why it matters

Potential benefit: If successful, this study could lead to more effective treatment options for patients suffering from carpal tunnel syndrome.

How similar studies have gone: Previous studies have shown varying degrees of success with corticosteroid injections for CTS, but the combination with nerve hydrodissection is less commonly tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Female and male patients aged 18-65 who applied to Ahi Evran University Physical Medicine and Rehabilitation Polyclinic and diagnosed with carpal tunnel syndrome through clinical and EMG
2. Patients who can understand the information form correctly and are cooperative
3. Patients who consented to participate in the study according to the informed consent form

Exclusion Criteria:

1. Cervical radiculopathy
2. Polyneuropathy
3. Brachial plexopathy
4. Systemic corticosteroid use
5. History of fracture and trauma in the forearm and wrist on the treated side 6- Inflammatory rheumatic disease

7- Pregnant and breastfeeding patients 8- Systemic diseases such as renal failure, peptic ulcer, diabetes, hypothyroidism, coagulation disorders 9- Patients who have undergone carpal tunnel syndrome surgery 10- Thoracic outlet syndrome 11- Thenar atrophy, severe carpal tunnel syndrome 12- Patient is unwilling or states that they cannot participate for any reason

Where it's running

  • Ahi Evran University
    Kırşehir, City Centre, Turkey (Türkiye)
    Recruiting
  • Ahi Evran University
    Kırşehir, Turkey (Türkiye)
    Recruiting

Study contacts

  • Principal investigator: Basak Cigdem Karacay, Assoc. Prof — Kirsehir Ahi Evran Universitesi
  • Study coordinator: Basak Cigdem Karacay, Assoc. Prof.
  • Email: basakcigdem@hotmail.com
  • Phone: +905445094803

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.