Comparing cardiac CT and transoesophageal echocardiography for detecting heart thrombi in stroke patients
Detecting Cardiac Thrombi in Acute Ischemic Stroke on Cardiac CT Versus Transoesophageal Echocardiography (MtH-DETECT)
This study is testing whether a heart scan called cardiac CT is better than a different heart test called TEE at finding blood clots in the hearts of stroke patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 39 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT06585228 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of cardiac computed tomography (CT) compared to transoesophageal echocardiography (TEE) in detecting cardiac thrombi in patients diagnosed with acute ischemic stroke. The study hypothesizes that cardiac CT may provide superior diagnostic yield due to its ability to visualize the left atrial appendage more effectively. Participants will undergo both cardiac CT and TEE to determine which method is more reliable for identifying thrombi that could lead to cardioembolic strokes. The study will include patients who have given informed consent and have been diagnosed with cardiac thrombus on initial imaging.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 years or older who have been clinically diagnosed with acute ischemic stroke and have a radiological diagnosis of cardiac thrombus.
Not a fit: Patients with conditions other than acute ischemic stroke or those with contraindications for TEE or repeat cardiac CT will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy for cardiac thrombi in stroke patients, potentially enhancing treatment outcomes.
How similar studies have performed: While there is limited data directly comparing cardiac CT to TEE for this specific purpose, the use of cardiac CT has shown promise in other studies for diagnosing cardiac conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Clinical diagnosis of acute ischemic stroke * Written informed consent from patient or representative * Radiological diagnosis of cardiac thrombus in the LA, including the LAA, on cardiac CT acquired during the initial stroke imaging protocol. Exclusion Criteria: * Patients with a diagnosis other than acute ischemic stroke, such as: transient ischemic attack, intracerebral haemorrhage, subarachnoid haemorrhage, epilepsy, tumor. * Absolute contraindication for TEE: * Perforated viscus * Esophageal stricture * Esophageal tumor * Esophageal perforation, laceration * Esophageal diverticulum * Active upper GI bleed * Absolute contraindication for repeat cardiac CT * Documented previous severe reaction to iodinated contrast media, including anaphylaxis, angioedema and bronchospasm. * Severely impaired kidney function defined as estimated glomerular filtration rate of 30 mL/min/1.73 m2.
Where this trial is running
Amsterdam, North Holland
- Amsterdam University Medical Center (UMC) — Amsterdam, North Holland, Netherlands (Recruiting)
Study contacts
- Principal investigator: Jonathan M Coutinho, MD, PhD — Amsterdam UMC
- Study coordinator: Shan Sui Nio, MD
- Email: s.nio@amsterdamumc.nl
- Phone: 020 5664591
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.