Comparing Calisthenics and High Intensity Interval Training for Non-Alcoholic Fatty Liver Disease

Calisthenics Versus High-intensity Interval Exercises on Health-related Outcomes in Patients With Non-alcoholic Fatty Liver

This study is testing whether calisthenics or high-intensity interval training can help people with non-alcoholic fatty liver disease improve their health over eight weeks.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 30 Years to 45 Years
• Sex: All
• Sponsor: Cairo University (Academic / other)
• Locations: 1 site (Giza)
• Trial ID: NCT06032650 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effects of two different exercise regimens, calisthenics and high intensity interval training (HIIT), on patients with non-alcoholic fatty liver disease (NAFLD). Sixty patients aged 30 to 40 will be randomly assigned to either exercise group and will participate in the program for eight weeks, while continuing their prescribed medication. Various assessments, including body composition, blood pressure, heart rate, and liver function, will be conducted before and after the intervention to measure the outcomes of each exercise type.

Who should consider this trial

Good fit: Ideal candidates are adults aged 30-40 with mild non-alcoholic fatty liver disease and specific body composition metrics.

Not a fit: Patients with severe liver disease or those not meeting the inclusion criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into effective exercise interventions for improving liver health in patients with NAFLD.

How similar studies have performed: Other studies have shown positive outcomes with exercise interventions for NAFLD, suggesting potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

* 1. Sixty patients with non-alcoholic fatty liver disease (NAFLD) of both genders.

  2. Patients with mild non-alcoholic fatty liver disease (NAFLD) according to ultrasonography fatty liver indicator (US-FLI) score (2-4).( Chen et al.,2020) 3. Their age will be ranged from 30s-40s. 4. Body mass index (BMI) from 30 to 34.9 kg/m2. 5. Body free fat mass (FFM) percentage \> 25 % for men,\> 35 % for women. 6. Lean body mass (LBM) parentage \< 76 % for men; \< 69% for women. 7. Waist circumference ≥ 102 cm for men, \> 88 cm for women. 8. Waist/Hip ratio \> 0.9% for men and \> 0.8% for women. 9. Elevated liver enzymes (ALT\> 55 U/L, AST\> 48 UL, GGT\>85 U/L, AST/ALT \<1 U/L).

  10. Patient with dyslipidemia who has one or more from the following blood lipid values (total cholesterol \> 200 mg\\dl, LDL \> 130 mg\\dl, TG \>150 mg\\dl, HDL\< 40mg\\dl or LDL/HDL ratio \> 4).

  11. Low levels of physical activity (using the International Physical Activity Questionnaire- Short Version (IPAQ)) ≤ 10 min walking per day.

  12. Liver size estimated by ultrasonography more than 5% from the normal liver size without hepatocellular damage.

Exclusion Criteria:

* The patient will be excluded if he has one of the following:-

  1. Unstable cardiovascular problems like arrhythmia and heart failure.
  2. Active Hepatitis C virus HCV.
  3. Diabetes mellitus (DM).
  4. Hypertensive patients (\>140/90mmHg).
  5. Active Smoker.
  6. Chronic chest disease.
  7. Patients on medications affecting muscle power as steroids.
  8. Auditory and visual problems.
  9. Pregnancy \& lactation.
  10. Clinically significant peripheral vascular disease (ABPI \< 80 %).
  11. Patients who take beta-blockers.
  12. Severe anemia.
  13. Patients with chronic renal failure.
  14. Musculoskeletal or neurological limitation to physical exercise.
  15. Any cognitive impairment that interferes with prescribed exercise procedures.
  16. .Participation in regular exercise training of any type in the previous 3 months

Where this trial is running

Giza

• Fatma Younis Mahmoud — Giza, Egypt (Recruiting)

Study contacts

• Principal investigator: Fatma Y mahmoud, AI — faculty of physical therapy
• Study coordinator: Fatma Y mahmoud, AI

Conditions Non-Alcoholic Fatty Liver Disease; NAFLD , Calisthenics , High intensity interval training