Comparing breathing muscle training methods for adults undergoing hematopoietic stem cell transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients undergoing hematopoietic stem cell transplantation often develop respiratory weakness, fatigue and reduced quality of life. This study compares three inspiratory muscle training protocols—standard IMT, functional IMT, and a sham IMT—delivered during the transplantation process to see which approach produces the best improvements. Eligible adults aged 18–65 without major orthopedic, neurological, cardiac, or chronic pulmonary comorbidities will be assigned to one of the training protocols while receiving standard medical care. Outcomes include respiratory muscle strength and endurance, dyspnoea, maximal exercise capacity, diaphragmatic and pulmonary function, peripheral muscle strength, fatigue, quality of life, and blood markers of oxidative stress and inflammation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Planned haematopoietic stem cell transplantation in the adult bone marrow transplant unit
* Between the ages of 18-65
* Under standard medical treatment, including immunosuppressives, antibiotics and other medications
* Ability to walk, co-operate and be clinically stable
* No history of orthopaedic, neurological, cardiac disorders

Exclusion Criteria:

* Cognitive disorders
* Have orthopaedic or neurological diseases that may affect the assessment of physical fitness tests
* Having comorbidities such as asthma, COPD
* Conditions in which exercise training is contraindicated, such as acute bleeding, haemoglobin value \<5 g/dl, platelet count ≤10000 mm3, high fever (body temperature \>38◦C), severe pain, confusion, dizziness, nausea and vomiting
* Patients with pneumonia or any acute infection

  -≥ 3 consecutive sessions of interruption of the exercise group subjects' attendance to the training protocol
* Loss of willingness to participate in the research during the research process
* Development of clinical haemodynamic instability in patients

Where it's running

• Istinye University
  Istanbul, Zeytinburnu, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ceren Derya Gültekin, MSc
• Email: cerenderya1@gmail.com
• Phone: +905383200141

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.