Comparing breathing muscle training methods for adults undergoing hematopoietic stem cell transplant
Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients
This trial tests whether different inspiratory muscle training programs help improve breathing strength, reduce breathlessness and fatigue, and boost exercise ability in adults having a hematopoietic stem cell transplant.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Istinye University Academic / other |
| Locations | 1 site (Istanbul, Zeytinburnu) |
| Trial ID | NCT07061444 on ClinicalTrials.gov |
What this trial studies
Patients undergoing hematopoietic stem cell transplantation often develop respiratory weakness, fatigue and reduced quality of life. This study compares three inspiratory muscle training protocols—standard IMT, functional IMT, and a sham IMT—delivered during the transplantation process to see which approach produces the best improvements. Eligible adults aged 18–65 without major orthopedic, neurological, cardiac, or chronic pulmonary comorbidities will be assigned to one of the training protocols while receiving standard medical care. Outcomes include respiratory muscle strength and endurance, dyspnoea, maximal exercise capacity, diaphragmatic and pulmonary function, peripheral muscle strength, fatigue, quality of life, and blood markers of oxidative stress and inflammation.
Who should consider this trial
Good fit: Adults 18–65 who are planned for hematopoietic stem cell transplantation, are able to walk and follow instructions, are clinically stable, and have no orthopedic, neurological, cardiac, or chronic pulmonary conditions are ideal candidates.
Not a fit: Patients with active pulmonary disease (like asthma or COPD), acute infections, cognitive impairment, or medical contraindications to exercise are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the preferred IMT protocol could strengthen breathing muscles, lessen breathlessness and fatigue, and speed functional recovery after transplant.
How similar studies have performed: Inspiratory muscle training has shown benefit in populations such as COPD and perioperative patients, but evidence specifically in HSCT recipients is limited and this application is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Planned haematopoietic stem cell transplantation in the adult bone marrow transplant unit * Between the ages of 18-65 * Under standard medical treatment, including immunosuppressives, antibiotics and other medications * Ability to walk, co-operate and be clinically stable * No history of orthopaedic, neurological, cardiac disorders Exclusion Criteria: * Cognitive disorders * Have orthopaedic or neurological diseases that may affect the assessment of physical fitness tests * Having comorbidities such as asthma, COPD * Conditions in which exercise training is contraindicated, such as acute bleeding, haemoglobin value \<5 g/dl, platelet count ≤10000 mm3, high fever (body temperature \>38◦C), severe pain, confusion, dizziness, nausea and vomiting * Patients with pneumonia or any acute infection -≥ 3 consecutive sessions of interruption of the exercise group subjects' attendance to the training protocol * Loss of willingness to participate in the research during the research process * Development of clinical haemodynamic instability in patients
Where this trial is running
Istanbul, Zeytinburnu
- Istinye University — Istanbul, Zeytinburnu, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Ceren Derya Gültekin, MSc
- Email: cerenderya1@gmail.com
- Phone: +905383200141
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.