Comparing brain stimulation techniques for impulsivity in borderline personality disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of a non-invasive brain stimulation technique called paired cortico-cortical associative stimulation (ccPAS) in reducing impulsivity among patients diagnosed with borderline personality disorder (BPD). Participants will be randomly assigned to receive either active ccPAS or a sham treatment, with the goal of enhancing connectivity between specific brain regions associated with impulsivity. The study will utilize a double-blind, parallel-group design to ensure unbiased results. By focusing on impulsivity, a key symptom of BPD, the trial seeks to provide insights into potential therapeutic interventions for this challenging condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of BPD (established by a psychiatrist and confirmed in a structured interview using the MINI) based on the Diagnostic and Statistical Manual of Mental Disorders (DSM V).

Exclusion Criteria:

* Contraindications to TMS/MRI (pacemakers or other devices likely to interfere with the magnetic field).
* Pregnant or breast-feeding women.
* Ongoing anxiolytic treatment (benzodiazepines), neuroleptic treatment or anticonvulsants acting on GABAergic transmission ; 24 hours prior to the protocol.
* Diagnosis of other chronic psychiatric pathology including bipolar disorder type I or II and addictions (except tobacco).
* Protective measure (curatorship or guardianship)

Where it's running

• Centre Hospitalier Le Vinatier
  Bron, Aura, France Recruiting

Study contacts

• Study coordinator: POULET Emmanuel, PUPH
• Email: emmanuel.poulet@chu-lyon.fr
• Phone: 0437915565

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.