Comparing Bone Marrow Aspirate Concentrate to Corticosteroid Injections for Knee Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of autologous bone marrow aspirate concentrate (BMAC) on patient-reported outcomes in individuals suffering from primary knee osteoarthritis. Participants will be randomly assigned to receive either BMAC injections or corticosteroid injections, with a follow-up period of six months to assess the outcomes. The study aims to enroll 100 patients, with 50 in each treatment group, and includes a crossover option for those initially receiving corticosteroids. The trial is designed to provide insights into the efficacy of BMAC compared to traditional corticosteroid therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients between the ages of 18-70
* Long standing knee pain from osteoarthritis (KL grade 2-3) despite conventional treatments such as activity modification, weight loss, physical therapy, analgesics, nonsteroidal anti-inflammatory drugs, or injection therapy for at least 6 weeks
* 7-day average pain score of at least 4 on VAS scale

Exclusion Criteria:

* Systemic diseases (Diabetes, malignancies, infections, etc.)
* Post-traumatic arthritis
* Patient had intra-articular injection on affected knee in last three months

Where it's running

• Rush University Medical Center
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Jorge Chahla, MD — Rush University Medical Center Associate Professor and Surgeon
• Study coordinator: Carla M. Edwards, PhD
• Email: carla_edwards@rush.edu
• Phone: 312-563-5735

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.