Comparing beef and vegetarian diets on muscle fatigue in older adults
The Effect of Beta-Alanine and Carnosine From Beef Intake on Muscle Fatigue in Older Adults
NA · Indiana University · NCT05860088
This study is testing whether eating beef or a vegetarian diet helps older adults feel less muscle fatigue and improves their muscle health.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Sponsor | Indiana University (other) |
| Locations | 1 site (Bloomington, Indiana) |
| Trial ID | NCT05860088 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of a beef diet versus a vegetarian diet on muscle fatigue in older adults aged 60-85. Participants will be randomly assigned to consume either diet for 8 weeks, followed by a 2-week washout period before switching diets for another 8 weeks. The study aims to determine if beef consumption can reduce muscle fatigue and improve biochemical markers related to muscle health. Body composition and functional muscle outcomes will be assessed, along with blood sample collection.
Who should consider this trial
Good fit: Ideal candidates are older adults aged 60-85 who can adhere to the study diet and meet specific health criteria.
Not a fit: Patients with significant orthopedic limitations or those unable to perform muscle fatigue tests may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary recommendations that enhance muscle health and reduce fatigue in older adults.
How similar studies have performed: While dietary interventions have been explored, this specific comparison of beef versus vegetarian diets on muscle fatigue in older adults is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Ages 60-85 years * Ability to eat study diet meals for a total of 16 weeks * Ability to perform sit-to-stand chair and 6-minute walking tests based on results from PAR-Q questionnaire * Ability to provide fasted blood samples * Access to transportation * Willing to abstain from alcohol consumption and/or use illicit drug use for each 8-week intervention period * Ability to consent to participating in this study * English-speaking * Body mass index between 18.5 (normal) and 39.9 (obese) kg/m2 * Minimum total body weight of 110 pounds * Non-anemia hemoglobin values: Females - \>12.0 grams/dL; Men - \>13.0 grams/dL * Able to ambulate without assistance * Physician's clearance for study participation (required prior to baseline testing) Exclusion Criteria * Inability or refusal to sign the informed consent * Significant orthopedic limitations or other contraindications to exercise * Inability or refusal to perform muscle fatigue tests * Has dietary restrictions that prevent to consumption of beef, soy and/or wheat * Has liver or kidney complications * Live or work \>25 miles from Bloomington study site or does not have transportation to the study site * Anticipate elective surgery during the study period * Diagnosis of progressive neurological disorders, musculoskeletal disorders, osteoarthritis, rheumatoid arthritis * Fracture or serious injury in the last 6 months * Stroke, revascularization, deep vein thrombosis, or pulmonary embolism in the past 12 months * Severe cardiovascular disease, uncontrolled systemic hypertension, chronic pulmonary disease * Plan to move residence or travel out of the local area during the study period * Current use of anti-coagulants (e.g. Coumadin or Warfarin) * Current use of prescription medications that affect heart rate or blood vessel dilation * Psychological or social characteristics that would interfere with their ability to fully participate in the study
Where this trial is running
Bloomington, Indiana
- Indiana University Bloomington — Bloomington, Indiana, United States (RECRUITING)
Study contacts
- Principal investigator: Cydne A Perry, PhD — Indiana University, Bloomington
- Study coordinator: Cydne A Perry, PhD
- Email: cydperry@iu.edu
- Phone: 812 855 5087
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Muscle Weakness, Muscle, Fatigue, Heart, Older Adults, Body Composition, Diet, Vegetarian, Meat