Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 to 65

Comparing Atorvastatin and Rosuvastatin's effects on Vitamin D levels in heart patients

Official title: Impact of Atorvastatin Versus Rosuvastatin on 25 Hydroxy Vitamin D Levels in Patients With Acute Coronary Syndrome

Run by King Edward Medical University · NCT06765265 · Data updated 2026-11-12

This study tests whether taking Atorvastatin or Rosuvastatin affects Vitamin D levels in heart patients with acute coronary syndrome.

More Acute Coronary Syndromes trials

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment152 (estimated)
SponsorKing Edward Medical University
Academic / other
Locations1 site (Lahore, Punjab Province)
StatusRecruiting
StartedJanuary 5, 2025
Main results expectedJanuary 1, 2026
Study endsJanuary 1, 2026
Registry record updatedMarch 11, 2025
Trial IDNCT06765265 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients with acute coronary syndrome and 25 OH-Vitamin D levels between 30-70 ng/ml.

Probably not a fit

Patients with conditions such as hypercalcemia, pregnancy, or those who have used certain medications recently may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of Atorvastatin versus Rosuvastatin on Vitamin D levels in patients diagnosed with acute coronary syndrome. A total of 152 patients with normal Vitamin D levels will be randomly assigned to receive either Atorvastatin (40 mg/day) or Rosuvastatin (20 mg/day) for a duration of six months. The primary outcome will be the change in 25-hydroxy Vitamin D levels after the treatment period. This study aims to provide insights into the relationship between statin therapy and Vitamin D levels in this patient population.

Why it matters

Potential benefit: If successful, this study could help optimize treatment strategies for patients with acute coronary syndrome by improving their Vitamin D levels.

How similar studies have gone: While there is existing research on statins and Vitamin D, this specific comparison of Atorvastatin and Rosuvastatin in acute coronary syndrome patients is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Acute Coronary Syndrome

25 OH-Vitamin D levels between 30-70ng/ml

Exclusion Criteria:

Hypercalcemia

hypocalcemia

pregnancy

lactation

hypersensitivity to statins

hypothyroidism

Deranged LFTs \& RFTs

Use of following within last 3 months (Vitamin D Supplements, lipid lowering drugs, anti-obesity drugs, corticosteroids)

Where it's running

  • King Edward Medical University
    Lahore, Punjab Province, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Aspirin 50 mg vs 100 mg with a P2Y12 inhibitor after PCI

    This trial tests whether a 50 mg daily aspirin dose, when used with a P2Y12 inhibitor after PCI, works as well as 100 mg with similar safety for people staying on DAPT for 12 months.

    Recruiting Jilin University · Changchun, Jilin · NCT07846462

  • Early Triple Lipid-Lowering Therapy After ACS

    This trial tests whether adding bempedoic acid to high-intensity statin and ezetimibe within 72 hours after PCI helps more adults with acute coronary syndrome reach LDL-C goals than the standard two-drug approach.

    Recruiting Phase 4 Taipei Medical University Hospital · Taipei, Taipei City · NCT07824323

  • Smartphone AI help for prehospital ECG readings

    This study tests whether using a smartphone AI (GPT-4o) to help prehospital providers read 12-lead ECGs improves accuracy in diagnosing acute coronary syndromes and related conditions.

    Recruiting École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care · Murten/Morat, Canton of Fribourg · NCT07810686

  • Early single antiplatelet therapy after IVUS-guided PCI in ACS

    This study tests whether stopping aspirin early and continuing a potent P2Y12 inhibitor alone is safe and effective after IVUS-guided PCI in people with acute coronary syndrome.

    Recruiting Phase 4 Gyeongsang National University Hospital · Jinju, Gyeongsangnam-do · NCT07684742

  • Local and systemic macrophage activation in coronary and peripheral artery disease

    This study tests whether macrophage activity inside coronary and peripheral arteries relates to circulating monocyte subtypes in people with stable and acute artery disease.

    Recruiting Maria Cecilia Hospital · Cotignola, Ravenna · NCT07588295

  • Long-term P2Y12 inhibitor monotherapy and blood clotting after angioplasty

    This trial will test whether specific P2Y12 drugs and reduced doses given alone keep platelet activity in a safe therapeutic range for people who completed initial dual antiplatelet therapy after PCI.

    Recruiting Phase 3 Cardiocentro Ticino · Lugano, Ch/ti · NCT07582835

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.