Comparing Aquablation and Holmium Laser for Enlarged Prostate Treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of aquablation versus Holmium laser enucleation of the prostate (HoLEP) in treating benign prostatic hyperplasia (BPH) in men with medium to large size prostates. Aquablation utilizes real-time ultrasound imaging and a robotic water jet to remove prostate tissue, while HoLEP is a well-established surgical method. The study aims to determine if aquablation can achieve similar patient-reported and functional outcomes as HoLEP, providing a potentially less invasive option for patients. Participants will be men aged 45 and older who are candidates for HoLEP and have specific prostate size and symptom criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men ≥45 years of age

  * Patient must be a candidate for HoLEP
  * Refractory to medical therapy or patient is not willing to consider (further) medical treatment
  * Patient has a prostate size of at least 50 ml and not more than 150ml, measured by transrectal ultrasound (TRUS)
  * IPSS ≥12
  * QoL≥3
  * Qmax ≤ 15 ml/s with a minimum voided volume ≥ 125 ml or patient in urinary retention
  * Written informed consent

Exclusion Criteria:

* Neurogenic lower urinary tract dysfunction

  * Urethral stenosis
  * Preinterventionally proven adenocarcinoma of the prostate
  * Nickel allergy
  * Not able to complete questionnaires due to cognitive or thought disorders
  * Language skills insufficient for informed consent and / or completion of questionnaires

Where it's running

• Cantonal Hospital St. Gallen
  Sankt Gallen, Switzerland Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.