Comparing Apixaban and Enoxaparin for preventing blood clots after spinal cord injury
Official title: Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury
Run by Loewenstein Hospital · NCT05484557 · Data updated 2026-11-12
This study is testing if a new blood thinner called Apixaban works better than the usual treatment, Enoxaparin, to prevent blood clots in people recovering from spinal cord injuries.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Loewenstein Hospital Academic / other |
| Locations | 1 site (Raanana) |
| Status | Recruiting |
| Started | September 6, 2023 |
| Main results expected | August 2027 |
| Study ends | February 2028 |
| Registry record updated | September 9, 2026 |
| Trial ID | NCT05484557 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are Hebrew-speaking individuals who have sustained a spinal cord injury and do not have contraindications for anticoagulant treatment.
✕Probably not a fit
Patients with active bleeding, significant bleeding risks, or those requiring other anticoagulant treatments will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of Apixaban compared to the standard treatment of Enoxaparin in preventing venous thromboembolism in patients recovering from spinal cord injuries. Participants in the sub-acute phase of spinal cord injury will receive either Enoxaparin or Apixaban for a duration of 6 to 12 weeks, depending on their injury severity. The study will monitor thromboembolism through D-Dimer tests and ultrasound doppler assessments, while also tracking any bleeding events and hematocrit levels throughout the treatment period.
Why it matters
Potential benefit: If successful, this study could provide a more effective anticoagulant option for preventing blood clots in spinal cord injury patients.
How similar studies have gone: While the use of anticoagulants in spinal cord injury is established, the specific comparison of Apixaban and Enoxaparin in this context is a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * spinal cord injury (traumatic of not traumatic), Hebrew speaker. Exclusion Criteria: * contra-indication for anticoagulant treatment * concomitant treatment with any other anticoagulant * anticoagulant treatment needed for indications other than VTE prevention following spinal cord injury * active clinically significant bleeding * any lesion or condition considered a significant risk factor for major bleeding. * hepatic disease associated with coagulopathy and clinically relevant bleeding risk * pregnancy or breast-feeding * heart valve related issues * galactose intolerance * active cancer * patients who require thrombolysis or pulmonary embolectomy * patients with renal impairment * sensitivity to excipients of the medication * anti phospholipid syndrome * prosthetic heart valve * acute ischemic stroke
Where it's running
-
Loewenstein Rehabilitation Hospital
Raanana, Israel Recruiting
Study contacts
- Study coordinator: Amiram Catz, MD PhD
- Email: amiramc@clalit.org.il
- Phone: 972-9-770-9934
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.