Comparing anesthesia techniques for pain management after knee replacement surgery
Official title: Enhanced Recovery After Surgery and Total Knee Replacement: A Prospective, Randomized Study on the Rule of Peripheral Nerve Blocks on Persistent Postoperative Pain Six Months After Surgery
Run by Policlinico di Monza SpA · NCT06182059 · Data updated 2026-11-12
This study tests which pain relief method works better after knee replacement surgery for patients, comparing two different types of anesthesia techniques.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 436 (estimated) |
| Sponsor | Policlinico di Monza SpA Academic / other |
| Locations | 1 site (Monza, Monza Brianza) |
| Status | Recruiting |
| Started | January 12, 2024 |
| Main results expected | January 31, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT06182059 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals scheduled for primary total knee replacement who can provide informed consent.
✕Probably not a fit
Patients with allergies to local anesthetics, contraindications to regional anesthesia, chronic opioid use, or a BMI over 35 kg/m² may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates two different regional anesthesia protocols for patients undergoing total knee replacement surgery. Participants will be randomized to receive either a continuous adductor canal block infusion combined with an ipack block or a continuous femoral nerve block with a sciatic nerve block. The goal is to determine which technique is more effective in reducing persistent postoperative pain six months after surgery. All patients will also receive multimodal analgesia to manage pain during recovery.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients recovering from knee replacement surgery.
How similar studies have gone: Previous studies have shown varying success with different regional anesthesia techniques, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * primary total knee replacement with a written informed consent Exclusion Criteria: * Allergy to local anesthetics or any drugs involve in the study * Controindication to regional anesthesia * chronic use of opioids * BMI \> 35 kg m2
Where it's running
-
Policlinico di Monza SPA
Monza, Monza Brianza, Italy Recruiting
Study contacts
- Study coordinator: Gianluca Cappelleri, MD
- Email: gianluca.cappelleri@policlinicodimonza.it
- Phone: +390392810941
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.