Comparing anesthesia techniques for pain management after knee replacement surgery
Enhanced Recovery After Surgery and Total Knee Replacement: A Prospective, Randomized Study on the Rule of Peripheral Nerve Blocks on Persistent Postoperative Pain Six Months After Surgery
This study tests which pain relief method works better after knee replacement surgery for patients, comparing two different types of anesthesia techniques.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 436 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Policlinico di Monza SpA Academic / other |
| Locations | 1 site (Monza, Monza Brianza) |
| Trial ID | NCT06182059 on ClinicalTrials.gov |
What this trial studies
This study investigates two different regional anesthesia protocols for patients undergoing total knee replacement surgery. Participants will be randomized to receive either a continuous adductor canal block infusion combined with an ipack block or a continuous femoral nerve block with a sciatic nerve block. The goal is to determine which technique is more effective in reducing persistent postoperative pain six months after surgery. All patients will also receive multimodal analgesia to manage pain during recovery.
Who should consider this trial
Good fit: Ideal candidates are individuals scheduled for primary total knee replacement who can provide informed consent.
Not a fit: Patients with allergies to local anesthetics, contraindications to regional anesthesia, chronic opioid use, or a BMI over 35 kg/m² may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients recovering from knee replacement surgery.
How similar studies have performed: Previous studies have shown varying success with different regional anesthesia techniques, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * primary total knee replacement with a written informed consent Exclusion Criteria: * Allergy to local anesthetics or any drugs involve in the study * Controindication to regional anesthesia * chronic use of opioids * BMI \> 35 kg m2
Where this trial is running
Monza, Monza Brianza
- Policlinico di Monza SPA — Monza, Monza Brianza, Italy (Recruiting)
Study contacts
- Study coordinator: Gianluca Cappelleri, MD
- Email: gianluca.cappelleri@policlinicodimonza.it
- Phone: +390392810941
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.