Clinical trial Recruiting at 1 site Interventional Ages 18 to 85

Comparing anesthesia techniques for pain management after knee replacement surgery

Official title: Enhanced Recovery After Surgery and Total Knee Replacement: A Prospective, Randomized Study on the Rule of Peripheral Nerve Blocks on Persistent Postoperative Pain Six Months After Surgery

Run by Policlinico di Monza SpA · NCT06182059 · Data updated 2026-11-12

This study tests which pain relief method works better after knee replacement surgery for patients, comparing two different types of anesthesia techniques.

Quick facts

Study typeInterventional
Ages18 Years to 85 Years
SexAll
Enrollment436 (estimated)
SponsorPoliclinico di Monza SpA
Academic / other
Locations1 site (Monza, Monza Brianza)
StatusRecruiting
StartedJanuary 12, 2024
Main results expectedJanuary 31, 2027
Study endsJuly 31, 2027
Registry record updatedSeptember 21, 2026
Trial IDNCT06182059 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals scheduled for primary total knee replacement who can provide informed consent.

Probably not a fit

Patients with allergies to local anesthetics, contraindications to regional anesthesia, chronic opioid use, or a BMI over 35 kg/m² may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates two different regional anesthesia protocols for patients undergoing total knee replacement surgery. Participants will be randomized to receive either a continuous adductor canal block infusion combined with an ipack block or a continuous femoral nerve block with a sciatic nerve block. The goal is to determine which technique is more effective in reducing persistent postoperative pain six months after surgery. All patients will also receive multimodal analgesia to manage pain during recovery.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management strategies for patients recovering from knee replacement surgery.

How similar studies have gone: Previous studies have shown varying success with different regional anesthesia techniques, but this specific comparison is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* primary total knee replacement with a written informed consent

Exclusion Criteria:

* Allergy to local anesthetics or any drugs involve in the study
* Controindication to regional anesthesia
* chronic use of opioids
* BMI \> 35 kg m2

Where it's running

  • Policlinico di Monza SPA
    Monza, Monza Brianza, Italy
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.