Comparing abbreviated MRI for Crohn's disease
Comparison of Conventional Clinical and Abbreviated MR Enterography Protocols in Children and Adults With Crohn's Disease
This study is testing a quicker MRI method using glucagon and water to see if it can effectively show inflammation in the small bowel for both kids and adults with Crohn's Disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 10 Years and up |
| Sex | All |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 2 sites (Rochester, Minnesota and 1 other locations) |
| Trial ID | NCT06533228 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of an abbreviated magnetic resonance imaging (MRI) protocol compared to the conventional standard of care MRI in documenting the presence and severity of small bowel inflammation in patients with Crohn's Disease. The abbreviated MRI will utilize glucagon and water instead of IV contrast, significantly reducing scan time from approximately 60 minutes to around 15 minutes. The study will include both children and adults who are already diagnosed with Crohn's Disease and are undergoing clinical MRE examinations for various reasons.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 10 and older with an established diagnosis of Crohn's Disease who require clinical magnetic resonance enterography examinations.
Not a fit: Patients who may not benefit from this study include those with isolated colonic disease, new diagnoses of Crohn's Disease undergoing baseline imaging, or those unable to undergo MRI due to contraindications.
Why it matters
Potential benefit: If successful, this study could provide a faster and more efficient imaging option for patients with Crohn's Disease, improving their overall experience and potentially leading to better management of their condition.
How similar studies have performed: Other studies have shown success with abbreviated MRI approaches, suggesting potential for this method to be effective in similar patient populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Established Crohn's disease diagnosis in patients 10 and older * Undergoing clinical magnetic resonance enterography (MRE) examinations for any reason(s) below * Staging/ restaging/ follow- up of intestinal inflammation * Evaluation of known or suspected luminal narrowing/ stricturing disease * Evaluation of known or suspected internal penetrating disease Exclusion Criteria: * Undergoing initial imaging for suspected Crohn's disease where the diagnosis of Crohn's disease has yet to be definitively established * New Crohn's disease diagnosis, undergoing baseline imaging * Isolated colonic disease * Known or suspected pregnancy * Contraindication to magnetic resonance imaging (MRI) * Ileostomy or prior ileal resection * Less than 10 years of age * Unable or unwilling to follow imaging procedures * Non- English speaking
Where this trial is running
Rochester, Minnesota and 1 other locations
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
- NYU Langone — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Jonathan Dillman — Cchmc
- Study coordinator: Tanita Dean
- Email: Tanita.Dean@cchmc.org
- Phone: (513) 803-0853
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.