Comparing 4D and 3D CT scans for assessing heart radiation dose in breast cancer treatment
4D CT Scan With Respiratory Gating Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy
This study is testing if 4D CT scans, which track breathing, are better than regular 3D CT scans at measuring radiation doses to the heart in women getting treatment for left-sided breast cancer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Central Hospital Saint Quentin Government |
| Drugs / interventions | radiation |
| Locations | 1 site (Saint-Quentin, Hauts-de-france) |
| Trial ID | NCT05726604 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of 4D CT scans, which monitor breathing motion, compared to standard 3D CT scans in assessing cardiac radiation doses for women undergoing radiation therapy for left-sided breast cancer. The focus is on determining whether the 3D CT scans accurately reflect the cardiac dose, particularly for the left anterior descending artery, which is crucial in preventing radiation-induced ischemic heart disease. By comparing these two imaging techniques, the study seeks to improve dosimetry assessments and potentially enhance patient safety during treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are female patients aged 18 and older diagnosed with left-sided breast cancer who require radiation therapy.
Not a fit: Patients who are under 18, pregnant, or breastfeeding will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate cardiac dosimetry, reducing the risk of radiation-induced heart disease in breast cancer patients.
How similar studies have performed: While the use of 4D CT scans is gaining traction, this specific comparison with 3D CT scans in the context of cardiac dosimetry for breast cancer treatment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 yo 2. Sex=female 3. Patients diagnoses with a left side breast cancer for which a radiation therapy is indicated and confirmed in a multidisciplinary consultation meeting. 4. Be able to understand and give her personal free consent, no judicial protection measure. 5. Written or oral consent, in compliance with the clinical investigation rules and regulation. 6. Patient affiliated with social security system 7. Treatment expected to be realized in Saint Quentin Hospital Exclusion Criteria: 1. Patient \< 18 yo 2. Pregnant women. 3. Breastfeeding women. 4. Consent not given 5. Claustrophobia 6. Incapacited subject or judicial protection measure 7. Other research with exclusion period time ongoing 8. All the inclusion criteria not met
Where this trial is running
Saint-Quentin, Hauts-de-france
- Saint Quentin Hospital — Saint-Quentin, Hauts-de-france, France (Recruiting)
Study contacts
- Study coordinator: Karim Boulanouar
- Email: ak.boulanouar@ch-stquentin.fr
- Phone: 0323067861
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.