Comparing 2 vs 4 cycles of Adebrelimab for esophageal cancer treatment

A Prospective, Multicenter, Exploratory Study Comparing 2 Cycles Versus 4 Cycles of Adebrelimab Combined With Chemotherapy as Neoadjuvant Treatment for Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

This study is testing whether getting 2 or 4 cycles of a new treatment combined with chemotherapy can help people with advanced esophageal cancer respond better before surgery.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Tang-Du Hospital (Academic / other)
• Drugs / interventions: Adebrelimab, chemotherapy, prednisone
• Locations: 1 site (Xi'an, Shannxi)
• Trial ID: NCT06663059 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the efficacy and safety of two different treatment regimens of Adebrelimab combined with chemotherapy for patients with resectable locally advanced thoracic esophageal squamous cell carcinoma. Participants will be randomly assigned to receive either 2 cycles or 4 cycles of the treatment before surgery. The primary goal is to determine the rate of pathological complete response (pCR) after treatment. The study will involve a screening period, treatment period, and follow-up to monitor safety and outcomes.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with histologically confirmed locally advanced thoracic esophageal squamous cell carcinoma who are planning to undergo surgery.

Not a fit: Patients with prior treatment for esophageal cancer or those with contraindications for surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve treatment outcomes for patients with esophageal cancer by identifying the most effective neoadjuvant therapy regimen.

How similar studies have performed: Other studies have shown promising results with neoadjuvant therapies in esophageal cancer, but this specific comparison of treatment cycles is novel.

Eligibility criteria

Inclusion Criteria:

1. Written informed consent must be signed, and the participant must voluntarily join the study.
2. Histologically or cytologically confirmed esophageal squamous cell carcinoma.
3. Locally advanced thoracic esophageal cancer assessed by CT/MRI/EUS, with clinical staging T1b-4aN+M0 or T2-4N0M0 (T2N0 patients must have high-risk factors such as lymphovascular invasion \[LVI\], tumor size ≥3 cm, or poor differentiation) (according to AJCC 8th edition).
4. Expected to achieve R0 resection.
5. Age between 18 and 75 years, regardless of gender.
6. ECOG Performance Status 0-1.
7. No prior treatment for esophageal cancer, including radiotherapy, chemotherapy, or surgery.
8. Planning to undergo surgery after completing neoadjuvant therapy.
9. No contraindications for surgery.
10. Normal major organ functions, including:

    * \*\*Hematology\*\* (no use of blood components, growth factors, white blood cell stimulants, platelet stimulants, or anemia-correcting drugs within 14 days before the first use of the study drug):
    * Neutrophil count ≥1.5 × 10\^9/L
    * Platelet count ≥100 × 10\^9/L
    * Hemoglobin ≥90 g/L
    * \*\*Biochemistry\*\*:
    * Total bilirubin ≤1.5 × ULN
    * ALT ≤2.5 × ULN, AST ≤2.5 × ULN
    * Serum creatinine ≤1.5 × ULN, or creatinine clearance ≥50 mL/min
    * \*\*Coagulation\*\*:
    * International Normalized Ratio (INR) ≤1.5 × ULN
    * Activated Partial Thromboplastin Time (APTT) ≤1.5 × ULN
11. Female participants of childbearing potential must have a negative serum pregnancy test within 72 hours before starting the study drug and must use effective contraception (e.g., intrauterine device, contraceptive pills, or condoms) during the study and for at least 3 months after the last dose. Male participants with a fertile partner must be surgically sterilized or agree to use effective contraception during the study and for 3 months after the last dose.
12. Good compliance with the study and cooperation with follow-up.

Exclusion Criteria:

1. Tumor clearly invading adjacent organs (e.g., major arteries or trachea).
2. Supraclavicular lymph node metastasis.
3. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage.
4. Poor nutritional status, BMI \< 18.5 kg/m²; if corrected with symptomatic nutritional support before randomization, may be considered for inclusion after assessment by the principal investigator.
5. History of allergy to monoclonal antibodies, Adebrelimab or its components, paclitaxel, cisplatin, or other platinum-based drugs.
6. Previous or current treatment with:

   * Any tumor-directed radiotherapy, chemotherapy, or other anti-tumor drugs.
   * Immunosuppressive drugs or systemic steroids (doses \> 10 mg/day of prednisone or equivalent) within 2 weeks prior to the first use of the study drug; inhaled or topical steroids and adrenal corticosteroids for non-active autoimmune diseases are allowed.
   * Live attenuated vaccines within 4 weeks prior to the first use of the study drug.
   * Major surgery or severe trauma within 4 weeks prior to the first use of the study drug.
7. Active autoimmune diseases or a history of autoimmune diseases, including but not limited to: interstitial pneumonia, colitis, hepatitis, pituitaryitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism (considered if on hormone replacement therapy); psoriasis or childhood asthma/allergy in complete remission without intervention can be considered, but those requiring bronchodilators for medical intervention cannot be included.
8. History of immunodeficiency, including positive HIV test, or other acquired or congenital immunodeficiencies, or history of organ transplantation or allogeneic bone marrow transplantation.
9. Poorly controlled cardiac symptoms or diseases, including but not limited to: (1) NYHA Class II or higher heart failure, (2) unstable angina, (3) myocardial infarction within 1 year, (4) clinically significant supraventricular or ventricular arrhythmias not controlled or poorly controlled after clinical intervention.
10. Severe infection (CTCAE \> 2) within 4 weeks prior to the first use of the study drug, such as severe pneumonia, bacteremia, or infection complications requiring hospitalization; active pulmonary inflammation on baseline chest imaging, symptoms and signs of infection within 14 days prior to the first use of the study drug, or need for antibiotic treatment, except for prophylactic use.
11. Active pulmonary tuberculosis infection discovered by medical history or CT, or history of active pulmonary tuberculosis within the past year, or history of active pulmonary tuberculosis more than 1 year ago without formal treatment.
12. Active hepatitis B (HBV DNA ≥ 2000 IU/mL or 10\^4 copies/mL) or hepatitis C (positive HCV antibody, and HCV RNA above the lower limit of detection).
13. Diagnosis of other malignant tumors within 5 years prior to the first use of the study drug, unless it is a low-risk malignancy (5-year survival rate \> 90%), such as fully treated basal cell carcinoma, squamous cell skin cancer, or cervical carcinoma in situ.
14. Pregnant or breastfeeding women.
15. Any condition that, in the investigator's judgment, may lead to withdrawal from the study, such as other serious illnesses (including mental illnesses) requiring concurrent treatment, alcohol or drug abuse, family or social factors that may affect the participant's safety or compliance.

Where this trial is running

Xi'an, Shannxi

• Tangdu Hospital Affiliated to the Fourth Military Medical University — Xi'an, Shannxi, China (Recruiting)

Study contacts

• Study coordinator: Tao Jiang, Dr

Conditions Esophageal Cancer; Esophageal Squamous Cell Carcinoma; Adebrelimab; Neoadjuvant