Compare PitNETs found in health checks vs. doctor visits
Official title: Role of Health Screening in Patients Undergoing Surgery for Pituitary Neuroendocrine Tumors: A Multicenter Cohort Study From the National Brain Tumor Registry of China (NBTRC)
Run by Beijing Tiantan Hospital · NCT07835412 · Data updated 2026-11-12
This study tests whether pituitary tumors found during health screening differ from those found after outpatient visits in surgery details and patient outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Year to 85 Years |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | September 22, 2026 |
| Main results expected | September 30, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07835412 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Patients with PitNETs who underwent surgical resection at Beijing Tiantan Hospital between 2011-2019 and NBTRC cases through 2021.
✕Probably not a fit
Patients with recurrent or synchronous brain tumors, missing key imaging data, emergency admissions, or those who declined participation may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational cohort uses the National Brain Tumor Registry of China to compare patients who had pituitary neuroendocrine tumors resected after incidental findings in health screening with those diagnosed through outpatient care. Grouping is based on the initial consultation department, with subgroups by specialty. Primary outcomes include preoperative tumor size, extent of resection, symptom onset to surgery, and hormonal remission at discharge; secondary outcomes cover surgery duration, hospital stay, and costs. Analyses will explore differences across functional hormone subtypes and multiple initial consultation categories, with the screening group as reference. Data from Beijing Tiantan Hospital and NBTRC cover cases from 2011–2021.
Why it matters
Potential benefit: If successful, results could help guide patient pathways and resource use for PitNETs detected through screening versus clinical care.
How similar studies have gone: Prior registry-based observational work has shown differences in presentation and management based on initial detection method for some brain tumors; this study extends that approach to PitNETs.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with PitNETs who underwent surgical resection at Beijing Tiantan Hospital from September 1, 2011, to November 30, 2019, together with those recorded in the NBTRC who underwent surgery from December 1, 2019, to December 31, 2021. Exclusion Criteria: 1. The department (health screening or outpatient clinics) where the definitive diagnosis confirmed was missing or unclear 2. PitNETs was recurrent or synchronous brain tumors of any histology existed 3. Admission was via the emergency department 4. Maximum tumor diameter on preoperative MRI were unavailable 5. Patients who explicitly declined to participate in this study
Where it's running
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the National Brain Tumor Registry of China (NBTRC)
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Wang Jia — Beijing Tiantan Hospital
- Study coordinator: Luwen Zhang
- Email: zhangluwen47@163.com
- Phone: +86 13051518751
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using hydrocortisone for hormone therapy in patients with large pituitary tumors
This study is testing if giving hydrocortisone to patients with large pituitary tumors before and after surgery can help prevent adrenal problems compared to a placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.