Using hydrocortisone for hormone therapy in patients with large pituitary tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the necessity of hydrocortisone replacement therapy during the perioperative period for patients undergoing surgery for large pituitary neuroendocrine tumors. Participants will receive either hydrocortisone or a placebo daily for two weeks and will be monitored for signs of adrenal insufficiency. Follow-up visits will occur three months post-surgery to assess outcomes and participants will maintain a diary of their symptoms throughout the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* (1) Age range: 18-70 years old;
* (2) Accept PitNETs patients who can be treated with endoscopic transsphenoidal surgery;
* (3) The maximum diameter of the tumor is ≥ 2 centimeters;
* (4) Preoperative hypothalamic pituitary adrenal axis integrity;
* (5) The subject or their legal representative signs the informed consent form

Exclusion Criteria:

* (1) Patients with a history of Cushing's disease or adrenal insufficiency;
* (2) Emergency and combined hormone therapy patients;
* (3) Pituitary stroke patients;
* (4) Patients lacking head magnetic resonance imaging;

Where it's running

• Beijing, Beijing Tiantan Hospital,Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: xingchao wang, Phd
• Email: wangxc@mail.ccmu.edu.cn
• Phone: 15101053127

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.