Compare arterial base excess in pregnant people with severe preeclampsia versus those with normal blood pressure
Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients
We will see if arterial base excess measured before delivery is different in pregnant people with severe preeclampsia compared with those who have normal blood pressure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Sex | Female |
| Sponsor | Saint Thomas Hospital, Panama Academic / other |
| Locations | 1 site (Panama City, Provincia de Panamá) |
| Trial ID | NCT07265336 on ClinicalTrials.gov |
What this trial studies
This prospective cohort study at Santo Tomás Hospital will collect arterial blood gas samples before delivery or surgery from pregnant people with severe preeclampsia and from normotensive pregnant controls. Researchers will measure base excess (BE), pH, lactate, and other blood gas parameters and record clinical variables and maternal outcomes. BE values will be correlated with measures of disease severity and adverse maternal events. The goal is to determine whether abnormal BE is associated with greater severity and worse outcomes in preeclampsia.
Who should consider this trial
Good fit: Pregnant people between 24 and 40 weeks' gestation who either have a diagnosis of severe preeclampsia or have normal blood pressure and are delivering at Santo Tomás Hospital.
Not a fit: Patients with metabolic or clinical conditions that alter acid-base balance (for example diabetic ketoacidosis, sepsis, renal failure, recent vomiting or diarrhea) or those who recently received bicarbonate are excluded and are unlikely to benefit from the study findings.
Why it matters
Potential benefit: If successful, base excess could be used as an additional marker to help identify pregnant people at higher risk of severe outcomes from preeclampsia.
How similar studies have performed: Prior work has examined arterial blood gas measures in obstetric emergencies, but relatively few studies have specifically linked base excess to preeclampsia severity, so this application is only partly established in the literature.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Gestational age: 24-40 weeks * Cases: Diagnosis of severe preeclampsia * Control: Normal blood pressure Exclusion Criteria: * Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure). * Clinical conditions that could hinder the results (diarrhea, vomit) * Recent use of bicarbonate
Where this trial is running
Panama City, Provincia de Panamá
- Saint Thomas Hospital — Panama City, Provincia de Panamá, Panama (Recruiting)
Study contacts
- Study coordinator: Francisco Jordan, MD
- Email: fcojordan19@gmail.com
- Phone: +507 6983-0029
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.