Combining tislelizumab with different treatment regimens for nasopharyngeal carcinoma

A Phase III Clinical Study of Tislelizumab Combined With GX Regimen Versus Tislelizumab Combined With GP Regimen in the First-line Treatment of Recurrence or Metastasis (R/M) Nasopharyngeal Carcinoma (NPC)

This study is testing two different treatment combinations with tislelizumab to see which one works better for patients with recurrent or metastatic nasopharyngeal carcinoma.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 266 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Fudan University (Academic / other)
• Drugs / interventions: chemotherapy, tislelizumab
• Locations: 1 site (Shanghai, Shanghai Municipality)
• Trial ID: NCT06177301 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and efficacy of two different treatment combinations for patients with recurrent or metastatic nasopharyngeal carcinoma. Participants will receive either tislelizumab combined with the GX regimen or tislelizumab combined with the GP regimen as their first-line treatment. The study aims to determine which combination is more effective in managing the disease while monitoring safety outcomes. Eligible patients must have measurable lesions and meet specific health criteria.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with confirmed recurrent or metastatic nasopharyngeal carcinoma who have not received prior systemic treatment.

Not a fit: Patients who have previously received systemic treatment for recurrent or metastatic nasopharyngeal carcinoma may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more effective treatment option for patients with nasopharyngeal carcinoma.

How similar studies have performed: Other studies have shown promising results with immunotherapy combinations in similar cancer types, suggesting potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. Histological or cytological examination confirmed recurrence or metastasis of nasopharyngeal carcinoma;
2. Patients who have not previously received systemic treatment for recurrent or metastatic diseases (For patients who have previously received induction chemotherapy, adjuvant chemotherapy or concurrent chemoradiotherapy, patients who relapsed at least 6 months after the cessation of chemotherapy can be enrolled).
3. Age: 18-75 years old, male or female;
4. Perfomance Status: 0\~1;
5. At least one measurable lesion (according to RECIST v1.1, long diameter of measurable lesion scanned by spiral CT should be ≥ 10 mm or short diameter of swollen lymph node should be ≥ 15 mm; according to RECIST vl.1 standards, a previously treated lesion with local treatment can be used as target lesions after clear progress);
6. Blood routine examination: 1) Hemoglobin (HB)≥ 90g / L; 2) Neutrophil count (ANC) ≥ 1.5 × 109 / L; 3) platelets (PLT) ≥ 80 × 109 / L;
7. Liver function: 1) Serum total bilirubin (BIL) ≤ 1.5 times the upper limit of normal (ULN); 2) alanine aminotransferase (ALT), aspartate aminotransferase (AST\])\< 2.5 × ULN; if liver metastasis, ALT and AST ≤ 5 × ULN; Renal function: Albumin ≥ 28g / L ；Serum creatinine (Cr) ≤ 1.5 × ULN，or creatinine clearance rate ≥ 60 ml / min ;
8. Coagulation function : APTT and international normalized ratio (INR)\< 1.5 × UNL;
9. Patients of childbearing age agree to take appropriate contraceptive measures. Serum pregnancy test was negative in women of childbearing age within 2 weeks before enrollment.
10. Patients agree to provide pathological tissue specimens (wax blocks or paraffin tissue sections 5-10 pieces) ;
11. Expected survival ≥ 3 months;
12. Patients volunteered to participate in this study and signed informed consent;

Exclusion Criteria:

1. Patients with local recurrence and suitable for surgery or radiotherapy;
2. Patients with a known history of severe allergies to monoclonal antibody therapy;
3. Patients who had previously received PD-1 monoclonal antibody or PD-L1 monoclonal antibody or CTLA4 monoclonal antibody;
4. Clinical significance of heart disease, including severe cardiac insufficiency : New York Heart Association (NYHA) cardiac insufficiency grade IV, unstable angina, acute myocardial infarction within 6 months before screening, congestive heart failure, Q-Tc interval greater than 500ms;
5. Patients with autoimmune diseases requiring treatment, or patients with a history of systemic use of steroids / immunosuppressive agents, such as : hypophysitis, pneumonia, colitis, hepatitis, nephritis, hyperthyroidism, hypothyroidism;
6. Other serious and uncontrollable concomitant diseases that may affect the compliance of the program or interfere with the interpretation of the results, including uncontrolled diabetes, or lung diseases (interstitial pneumonia, obstructive pulmonary disease, and symptomatic bronchial spasm) ;
7. Known hepatitis B (HBV) (HBsAg positive and HBV-DNA ≥ 103IU / ml), hepatitis C ( HCV) infection (HCV antibody positive and HCV-RNA measurable) ; and other subjects with acquired and congenital immunodeficiency diseases, including, but not limited to, those infected with HIV;
8. Severe active infection;
9. Symptomatic patients with central nervous system metastasis;
10. Patients with a history of other malignant tumors (unless those who have been cured for more than 5 years);
11. Have a serious history of neurological or psychiatric disorders, including dementia or epilepsy;
12. Drug abuse, medical, psychological or social conditions that may interfere with the participant 's participation in the study or the evaluation of the study results;
13. Researchers believe that patients who are not suitable for enrollment.

Where this trial is running

Shanghai, Shanghai Municipality

• Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China (Recruiting)

Study contacts

• Principal investigator: Dongmei Ji, M.D — Fudan University
• Study coordinator: Dongmei Ji, M.D

Conditions Nasopharyngeal Carcinoma