Combining surufatinib, sintilimab, and AG for treating advanced pancreatic cancer

A Single-center, Single-arm, Phase II Clinical Study of Surufatinib Combined With Sintilimab and AG in First-line Therapy of Patients With Locally Advanced or Metastatic Pancreatic Cancer

This study is testing a new combination of three medications to see if it can help people with advanced pancreatic cancer feel better and live longer.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 32 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Sun Yat-sen University (other)
• Drugs / interventions: chemotherapy, sintilimab, surufatinib
• Locations: 1 site (Guangzhou, Guangdong)
• Trial ID: NCT05481476 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness and safety of a combination therapy using surufatinib, sintilimab, and AG as a first-line treatment for patients with locally advanced or metastatic pancreatic cancer. It is a single-center, open-label, phase 2 study that aims to enroll patients who have not previously received systemic therapy for their condition. The study will assess the response of the treatment in patients with measurable liver metastases and evaluate overall survival rates. Participants will be closely monitored for any adverse effects throughout the treatment period.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 to 75 with unresectable, locally advanced or metastatic pancreatic cancer who have not received prior systemic therapy.

Not a fit: Patients with serious organic diseases or those who have received previous systemic therapy for their pancreatic cancer may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new effective option for patients with advanced pancreatic cancer, potentially improving survival rates.

How similar studies have performed: While this approach is novel, similar combination therapies have shown promise in other cancer types, suggesting potential for success in this context.

Eligibility criteria

Inclusion Criteria:

1. Informed consent has been signed
2. Histologically or cytologically confirmed unresectable, locally advanced or metastatic pancreatic cancer
3. Age ≥ 18 years, ≤75 years, male or female
4. ECOG PS：0-1, expected overall survival ≥12 months
5. Patients who have not previously received systemic therapy for locally advanced or metastatic pancreatic cancer
6. Patients with distant metastases after surgery, who have received one regimen of adjuvant chemotherapy and have recurred \> 6 months from adjuvant therapy can be enrolled
7. Patients must have at least one measurable liver metastases (RECIST 1.1)
8. No serious organic diseases of the heart, lungs, brain and other organs
9. Patients must have adequate organ and bone marrow function
10. Women of childbearing age must have a negative pregnancy test within the first day of the study, and contraceptive methods should be taken during the study until 6 months after the last administration

Exclusion Criteria:

1. Participated in clinical trials of other anti-tumor drugs within 4 weeks before enrollment
2. Previously received VEGFR inhibitors or immune checkpoint inhibitors
3. Patients with BRCA1/2 germline mutations
4. Patients with obstructive jaundice but less than expected jaundice
5. Patients had other malignant tumors in the past 5 years, except for the cured skin basal cell carcinoma and cervical carcinoma in situ
6. Patients previously had brain metastasis or current brain metastasis
7. Investigator determines that the liver metastases account for 70% or more of the total liver volume
8. Received any operation (except biopsy) or invasive treatment or operation (except venous catheterization, puncture and drainage, internal/external drainage surgery for obstructive jaundice, etc.) within 4 weeks before enrollment
9. Received local anti-tumor therapy such as hepatic artery interventional embolization, cryoablation or radiofrequency ablation of liver metastases within 4 weeks before enrollment
10. Clinically significant electrolyte abnormality
11. Patient currently has uncontrolled hypertension, defined as: systolic blood pressure \> 140mmHg or diastolic blood pressure \> 90mmHg
12. Proteinuria ≥ 2+ (1.0g/24hr)
13. Patients whose tumor is highly likely to invade important blood vessels and cause fatal hemorrhage during the follow-up study period as judged by the investigator
14. Have evidence or history of bleeding tendency within 3 months, Significant bleeding symptoms or a clear bleeding tendency within 3 months before enrollment
15. Clinically significant cardiovascular disease, including but not limited to acute myocardial infarction, severe/unstable angina pectoris or coronary artery bypass grafting within 6 months before enrollment; NYHA classification \> 2 Grade; ventricular arrhythmia requiring medical therapy; ECG showing QTc interval ≥ 480 ms
16. Active or uncontrolled serious infection (≥CTCAE grade 2 infection)
17. Unrelieved toxic reactions ≥ CTCAE grade 2 due to any previous anticancer treatment, excluding alopecia, lymphopenia and neurotoxicity of ≤ grade 2 caused by oxaliplatin
18. Pregnant or lactating women
19. Any other disease, with clinically significant metabolic abnormalities, physical examination abnormalities or laboratory abnormalities, according to the judgment of investigator that the patient is not suitable for the the study drug (such as having epileptic seizures and require treatment), or would affect the interpretation of study results, or put patients at high risk
20. Clinical confirmed human immunodeficiency virus (HIV) infection, history of clinically significant liver disease, including viral hepatitis (hepatitis B / C (HBV DNA Positive\[1×104 copies/mL or \>2000 IU/ml\], HCV RNA positive\[\>1×103 copies/mL\]), or other hepatitis, cirrhosis\])
21. Patients with autoimmune disease or suspected autoimmune disease (including but not limited to: myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, enteritis, multiple Sclerosis, vasculitis, glomerulonephritis, uveitis, hypophysitis, hyperthyroidism, etc.)
22. Patients who are allergic or suspected to be allergic to the study drug or similar drugs
23. Patients have other factors that may affect the results of the study or cause the study to be terminated halfway, such as alcoholism, drug abuse, other serious diseases (including mental diseases) that require concomitant treatment, and serious laboratory abnormalities. Accompanied by family or social factors, which will affect the safety of patients

Where this trial is running

Guangzhou, Guangdong

• Cancer center of SunYat-sen University — Guangzhou, Guangdong, China (RECRUITING)

Study contacts

• Study coordinator: Dongsheng Zhang, PhD

Conditions: Pancreatic Neoplasms