Combining radiation and hyperthermia for advanced cervical cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of combining radiation therapy or chemoradiation with interstitial brachytherapy and hyperthermia in patients with advanced cervical cancer. The aim is to enhance the treatment outcomes by leveraging the radio- and chemosensitive effects of hyperthermia. Eligible participants include those with histologically confirmed cervical carcinoma at specific stages, and the study will assess the clinical outcomes of this combined approach. The interventions include radiation, brachytherapy, Cisplatin, and hyperthermia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histological confirmed carcinoma of the Cervix
* FIGO-Stage IIB-IVA; earlier stages when inoperable or according to patient's wish
* clinical M0; except: involvement of para-aortic lymph nodes
* Age ≥ 18 years
* ECOG ≤ 2
* Informed consent of the patient

Exclusion Criteria:

* Pre-existing uncontrolled cardiac disease, signs of cardiac failure, or rhythm disturbances requiring therapy
* Cardiac Pacemaker
* Myocardial infarction within the past 12 months
* Congestive heart failure
* Complete bundle branch block
* New York Heart Association (NYHA) class III or IV heart disease
* Disease that would preclude chemoradiation or deep regional hyperthermia
* Metal implants (length \> 2cm or dense clusters of marker clips in the pelvis)
* Active or therapy-resistent bladder infections
* Pre-existing or concommitant immunodeficiency Syndrome
* Pregnant or lactating women
* Patients not willing to use effective contraception during and up to 6 months after therapy

Where it's running

• Universitätsklinikum Erlangen, Strahlenklinik
  Erlangen, Germany Recruiting

Study contacts

• Study coordinator: Oliver Ott, MD
• Email: st-studiensekretariat@uk-erlangen.de
• Phone: ++49 9131 85

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.