Combining physical therapy with stem cell treatment for knee osteoarthritis
Effectiveness of Physical Therapy on Stem Cell Transplantation Recipients in Improving Pain, Quadriceps Muscle Strength and Functional Status of Knee Osteoarthritis: A Randomized Controlled Trial
This study is testing if combining physical therapy with stem cell treatment can help people with knee osteoarthritis feel less pain and move better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | Dow University of Health Sciences Academic / other |
| Locations | 2 sites (Karachi, Sindh and 1 other locations) |
| Trial ID | NCT05959902 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of physical therapy in patients who have received mesenchymal stem cell treatment for knee osteoarthritis. It is a randomized controlled trial involving 48 participants, who will be divided into two groups: one receiving standard walking exercises and the other undergoing a structured physiotherapy regimen. The study aims to assess improvements in pain, muscle strength, and functional status over an 8-week treatment period. Data will be collected using established scoring systems to measure outcomes.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 40 and above with knee osteoarthritis who have received mesenchymal stem cell transplantation.
Not a fit: Patients with neurological disorders, musculoskeletal deformities, or a history of lower limb surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain management and functional mobility for knee osteoarthritis patients who have undergone stem cell therapy.
How similar studies have performed: While the combination of physical therapy and stem cell treatment is a novel approach, previous studies have shown promise in using stem cell therapies for osteoarthritis management.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects of age 40 years and above. * Male and female both will be included. * Patients with single or both knee OA. * Patients who had mesenchymal stem cell transplantation. * Kellgren and Lawrence grade II, III on radiological findings. Exclusion Criteria: * Patients with any neurological disorder. * Any musculoskeletal deformity (varus/valgus). * Patients who have had any type of lower limb internal fixation. * Patients who have had any type of lower limb arthroplasty or other knee surgery in the past. * Patients with a history of any infectious or malignant condition.
Where this trial is running
Karachi, Sindh and 1 other locations
- Dow Institute of Physical Medicine and Rehabilitation, DUHS. — Karachi, Sindh, Pakistan (Recruiting)
- Alkhaleej Ortho Stem Cell Clinic — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Study coordinator: Syed Muhammad Zaeem Hasan Zaidi, DPT
- Email: hxaeem@gmail.com
- Phone: 03320319277
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.