Combining knee exercises with rhythmic cues to improve muscle strength

The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues on Vastus Medialis Muscle Motor Unit Behavior in Healthy Individuals

Not applicable Interventional Mahidol University · NCT06565325

This study tests if doing knee exercises with a rhythm from a metronome can help people strengthen their muscles and improve control over their movements.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment30 (estimated)
Ages18 Years to 30 Years
SexAll
SponsorMahidol University Academic / other
Locations1 site (Nakhon Pathom, Salaya)
Trial IDNCT06565325 on ClinicalTrials.gov

What this trial studies

This study investigates the immediate effects of combining terminal knee extension exercises with audible cues to enhance muscle strength and neuromuscular control. Participants will perform exercises while following a metronome rhythm, which is expected to improve motor unit behavior in the vastus medialis muscle. The study aims to provide insights into how sensory input can optimize therapeutic exercise outcomes in physical therapy. By examining the effects of this combined approach, the researchers hope to contribute to better rehabilitation strategies for muscle weakness.

Who should consider this trial

Good fit: Ideal candidates are healthy individuals aged 18 to 30 with a BMI between 18.5 and 25 who are lightly active or sedentary.

Not a fit: Patients with a history of serious lower back or lower extremity injuries or musculoskeletal problems in the past six months may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more effective rehabilitation techniques for individuals with muscle weakness.

How similar studies have performed: While the specific combination of terminal knee extension exercises with audible cues is novel, similar studies have shown that sensory input can enhance exercise efficacy.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged range between 18 and 30 years
* BMI of 18.5-25 kg/m2
* Male or female
* Lightly active or sedentary {Physical activity level (PAL= 1.4-1.69)}

Exclusion Criteria:

* History of serious injury or operation of lower back and lower extremities such as fracture
* Musculoskeletal problems of lower back and lower extremities in 6 months before the study
* Single-leg stance test \< 43 seconds (26). and range of weight-bearing lunge test \< 9.1 cm

Where this trial is running

Nakhon Pathom, Salaya

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Muscle WeaknessTerminal Knee Extension ExerciseAudible CuesTherapeutic exerciseMuscle strength
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.