Combining Ivonescimab with Radiation and Chemotherapy for Pancreatic Cancer
Efficacy and Safety of Ivonescimab(AK112/SMT112) in Combination With Stereotactic Body Radiation Therapy and Chemotherapy in Patients With Pancreatic Cancer：A Single-arm, Open-label, Phase II Clinical Study
This study is testing if combining a new drug called ivonescimab with radiation and chemotherapy can help people with pancreatic cancer feel better and improve their treatment outcomes.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy, radiation, prednisone, ivonescimab |
| Locations | 1 site (Wuhan) |
| Trial ID | NCT06491472 on ClinicalTrials.gov |
What this trial studies
This Phase II clinical trial evaluates the safety and efficacy of ivonescimab (AK112/SMT112) when used alongside stereotactic body radiation therapy (SBRT) and chemotherapy in patients diagnosed with pancreatic cancer. The study is open-label and single-arm, meaning all participants will receive the same treatment without a control group. Eligible patients must have a confirmed diagnosis of pancreatic ductal adenocarcinoma and meet specific health criteria. The trial aims to assess how well this combination therapy works in treating locally advanced or metastatic pancreatic cancer.
Who should consider this trial
Good fit: Ideal candidates for this study are adults with histologically confirmed pancreatic ductal adenocarcinoma who have a life expectancy of at least three months and an ECOG performance status of 0 or 1.
Not a fit: Patients with known active brain metastases or those who have previously received radiotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment approach could improve outcomes for patients with pancreatic cancer by enhancing the effectiveness of existing therapies.
How similar studies have performed: While there have been studies exploring similar combinations of therapies for pancreatic cancer, the specific use of ivonescimab in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be able and willing to provide written informed consent and comply with all requirements of study participation (including all study procedures). * Histologically- or cytologically-confirmed diagnosis of pancreatic ductal adenocarcinoma (including adenosquamous carcinoma) * Have a life expectancy of at least 3 months. * Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 assessed by investigator * No previous history of radiotherapy or no overlap between the secondary radiotherapy site and the original radiotherapy site * Has adequate organ function * All female and male subjects of reproductive potential must agree to use an effective method of contraception, as determined by the Investigator, during and for 120 days after the last dose of study treatment. Exclusion Criteria: * Has known active brain metastases or meningeal metastases * Compression fractures of the spine not treated with surgery and/or radiation; Treated spinal compression fractures require stable disease for at least 2 weeks randomization * There was a high risk of gastrointestinal bleeding or abdominal bleeding * Uncontrolled cancer pain; Anesthetic painkillers did not reach a stable dose at the time of enrollment * During the initial 72 hours of the study, patients experienced a weight loss of 10 percent or more compared to their initial body weight when they signed the ICF * Within 72 hours prior to the study, the subjects' ECOG physical status score increased by ≥1 point compared to the score at ICF signing. * Unable to lie flat or for 10-20 minutes with radiotherapy. * Prior exposure to any agent targeting T cell costimulation or immune checkpoint pathways (e.g., anti-PD 1, anti-PD L1, anti-PD L2, anti-CTLA 4, anti CD137 or anti-OX40 antibody, etc) * Known germ line BRAC1/2 mutation * Liver metastases account for more than 50% of the total liver volume * Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy within 2 years before the first dose of study treatment; * Received chemotherapy, tyrosine kinase inhibitors, immunotherapy (such as interleukin, interferon or thymosin) and other anti-tumor therapy within 28 days before the study, and received Chinese medicine with anti-tumor indications within 14 days before the administration * Has undergone major surgery within 30 days prior to the first dose of study treatment * Has received radical radiotherapy within 3 months before the study; Palliative radiotherapy was allowed 2 weeks before administration, and the radiotherapy dose was in line with local palliative treatment standards * Systemic corticosteroids (\>10 mg/ day of prednisone or equivalent equivalent of other corticosteroids, continuous treatment ≥7 days) or immunosuppressant therapy were required during the first 14 days of the study; Except inhaled or topical use of hormones, or physiological replacement dose of hormone therapy due to adrenal insufficiency; Short-term (≤7 days) corticosteroids are permitted for prevention (e.g., contrast agent allergy) or treatment of non-autoimmune conditions (e.g., delayed hypersensitivity caused by exposure to allergens) * has a decline in albumin that was difficult to correct * Has received a live virus vaccine within 28 days prior to first dose of study treatment. * Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) * Has an active infection requiring systemic therapy * Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA \[qualitative\] is detected) * History of myocardial infarction, unstable angina, cardiac or other vascular stenting, angioplasty, or surgery within 6 months prior to day 1 of study treatment * Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of this subject to participate, in the opinion of the treating investigator * Has received a live virus vaccine within 28 days prior to first dose of study treatment * Is pregnant, breastfeeding, or expecting to conceive or father a child within the projected duration of the study including 120 days following the last dose of study treatment. * Other cases deemed inappropriate by the investigator.
Where this trial is running
Wuhan
- Wuhan Union Hospital of China — Wuhan, China (Recruiting)
Study contacts
- Study coordinator: Tao Zhang
- Email: 1277577866@qq.com
- Phone: 13808640033
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.