Combining cognitive rehabilitation and exercise to improve learning and memory in multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a combined cognitive rehabilitation approach using the Kessler Foundation modified Story Memory Technique (KF-mSMT®) alongside exercise programs in enhancing new learning and memory (NLM) in individuals with multiple sclerosis (pwMS) who experience mobility disability. Participants will engage in either aerobic exercise training with virtual reality or stretching and toning exercises while receiving cognitive rehabilitation. The goal is to determine if this novel combination can lead to greater functional recovery compared to cognitive rehabilitation alone. This approach is innovative as it seeks to address the limitations of current cognitive rehabilitation methods by integrating physical activity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be within the ages of 18 and 70 years of age
* Speak English as their primary language
* Confirmed MS diagnosis by a neurologist
* Be relapse and steroid-free for at least 30 days
* Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS)
* Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ)
* Right handedness

Exclusion Criteria:

* History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
* Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
* Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
* Currently pregnant
* Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe)
* Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)

Where it's running

• Kessler Foundation
  East Hanover, New Jersey, United States Recruiting

Study contacts

• Principal investigator: Carly Wender, PhD — Kessler Foundation
• Study coordinator: Carly Wender, PhD
• Email: cwender@kesslerfoundation.org
• Phone: (973) 324-8388

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.