Combining cognitive rehabilitation and exercise to improve learning and memory in multiple sclerosis
A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis
This study is testing if combining brain training with exercise can help people with multiple sclerosis improve their learning and memory skills.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 78 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Kessler Foundation Academic / other |
| Locations | 1 site (East Hanover, New Jersey) |
| Trial ID | NCT06197685 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of a combined cognitive rehabilitation approach using the Kessler Foundation modified Story Memory Technique (KF-mSMT®) alongside exercise programs in enhancing new learning and memory (NLM) in individuals with multiple sclerosis (pwMS) who experience mobility disability. Participants will engage in either aerobic exercise training with virtual reality or stretching and toning exercises while receiving cognitive rehabilitation. The goal is to determine if this novel combination can lead to greater functional recovery compared to cognitive rehabilitation alone. This approach is innovative as it seeks to address the limitations of current cognitive rehabilitation methods by integrating physical activity.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18 to 70 with a confirmed diagnosis of multiple sclerosis, mild-to-moderate mobility disability, and who are currently physically inactive.
Not a fit: Patients with severe cognitive impairment, other neurological disorders, or contraindications to exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly enhance cognitive function and quality of life for patients with multiple sclerosis.
How similar studies have performed: While cognitive rehabilitation has shown benefits in similar populations, this specific combinatory approach is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be within the ages of 18 and 70 years of age * Speak English as their primary language * Confirmed MS diagnosis by a neurologist * Be relapse and steroid-free for at least 30 days * Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS) * Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ) * Right handedness Exclusion Criteria: * History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression) * Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q) * Currently use medications that may impact cognition (ex: steroids, benzodiazepines) * Currently pregnant * Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe) * Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)
Where this trial is running
East Hanover, New Jersey
- Kessler Foundation — East Hanover, New Jersey, United States (Recruiting)
Study contacts
- Principal investigator: Carly Wender, PhD — Kessler Foundation
- Study coordinator: Carly Wender, PhD
- Email: cwender@kesslerfoundation.org
- Phone: (973) 324-8388
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.