Combining antidepressants with attention bias training for depression treatment
Combining Antidepressants and Attention Bias Modification in Depression: a Randomized Controlled Trial in Primary Care
NA · University of Oslo · NCT05503966
This study is trying to see if adding attention training to standard antidepressant treatment can help people with Major Depressive Disorder feel better than just taking antidepressants alone.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 246 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University of Oslo (other) |
| Locations | 1 site (Oslo, Nydalen) |
| Trial ID | NCT05503966 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of combining attentional bias modification (ABM) training with standard antidepressant treatment for patients with Major Depressive Disorder (MDD) in primary health care settings. It aims to determine if this combined approach leads to greater symptom improvement compared to antidepressants alone or an active comparison condition. A total of 246 patients aged 18 to 65 with a diagnosis of MDD will be randomly assigned to one of three treatment groups in a pragmatic randomized controlled trial. The study seeks to enhance treatment outcomes for a challenging population often treated in primary care.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 65 diagnosed with Major Depressive Disorder who can understand and speak a Scandinavian language.
Not a fit: Patients with current or past neurological illnesses, substance dependency disorders, or psychotic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective treatment options for patients suffering from Major Depressive Disorder.
How similar studies have performed: Other studies have shown promise in using attentional bias modification as an adjunct treatment for depression, suggesting potential success for this combined approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Major Depressive Disorder * BDI II \> 14 * Age 18 - 65 years * Ability to understand and speak a Scandinavian language * Willingness and ability to give informed consent Exclusion Criteria: * Current or past neurological illness * Traumatic brain injury * Current alcohol and/or substance dependency disorders * Psychotic disorders * Bipolar disorder type 1, * Developmental disorders and mental retardation.
Where this trial is running
Oslo, Nydalen
- Jan Ivar Røssberg — Oslo, Nydalen, Norway (RECRUITING)
Study contacts
- Principal investigator: Jan I Røssberg, PhD — Universitetet i Oslo/Oslo universitetssykehus
- Study coordinator: Jan I Røssberg, PhD
- Email: j.i.rossberg@medisin.uio.no
- Phone: +47 47876866
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Depressive Disorder, Major Depressive Disorder, Attentional Bias Modification, Primary Health Care