Combined physical and psychological treatment for carpal tunnel syndrome pain

Evaluating the Effectiveness of a Combined Physical and Psychological Intervention in Carpal Tunnel Syndrome Patients With Nociplastic Pain: A Randomized Controlled Trial

Not applicable Interventional Ahram Canadian University · NCT05915611

This study is testing a new treatment that combines physical therapy and mental health support to see if it can help adults with carpal tunnel syndrome and related pain feel better and function more effectively.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment64 (estimated)
Ages25 Years to 65 Years
SexAll
SponsorAhram Canadian University Academic / other
Locations1 site (Al Ḩayy Ath Thāmin, Giza)
Trial IDNCT05915611 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of a combined physical and psychological intervention aimed at reducing pain and enhancing function in patients suffering from carpal tunnel syndrome with nociplastic pain. Participants will receive both standard care and the new intervention, which focuses on addressing both physical and psychological aspects of their condition. The study will include adults aged 25-65 who meet specific diagnostic criteria for carpal tunnel syndrome and nociplastic pain as assessed by the Central Sensitization Inventory.

Who should consider this trial

Good fit: Ideal candidates are adults aged 25-65 diagnosed with carpal tunnel syndrome and experiencing nociplastic pain.

Not a fit: Patients who have previously undergone carpal tunnel release surgery or have other upper extremity disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly alleviate pain and improve daily functioning for patients with carpal tunnel syndrome.

How similar studies have performed: While this approach is innovative, similar combined interventions have shown promise in other pain management studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged 25-65 years
* Both sexes
* Diagnosis of carpal tunnel syndrome based on clinical examination and nerve conduction studies
* Presence of nociplastic pain as determined by the Central Sensitization Inventory (CSI) with a score ≥40
* Positive tinel and phalen sign.

Exclusion Criteria:

* Previous carpal tunnel release surgery
* Other musculoskeletal or neurological disorders affecting the upper extremity

Where this trial is running

Al Ḩayy Ath Thāmin, Giza

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Carpal Tunnel SyndromePain, Chronic
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.