Combined mobile exercise and cognitive rehabilitation for older cancer survivors
An Exercise and COgnitive Rehabilitation Intervention for Older Cancer Survivors (The E-Co Study)
This pilot will test a combined mobile exercise and cognitive rehabilitation program to see if it improves thinking and memory in older cancer survivors who have finished treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | University of Rochester Academic / other |
| Locations | 1 site (Rochester, New York) |
| Trial ID | NCT05388214 on ClinicalTrials.gov |
What this trial studies
This single-arm pilot refines and tests a multicomponent intervention (E-Co) that integrates mobile health–delivered exercise with cognitive rehabilitation for older adults who completed cancer-directed treatments. Participants aged 60 and older with self-reported concerns about memory or thinking will be enrolled and cleared for exercise by their oncologist. The study will measure feasibility outcomes such as adherence and self-efficacy, along with preliminary cognitive outcomes to see if the combined program produces benefit. Investigators aim to streamline the intervention to make it manageable for older survivors and improve sustained exercise participation.
Who should consider this trial
Good fit: Adults aged 60 or older who completed curative-intent cancer treatment, report post-treatment memory or thinking concerns, can walk 4 meters, speak English, and receive oncologist clearance for exercise are ideal candidates.
Not a fit: Those with active uncontrolled medical issues, severe physical or psychological impairments that prevent participation, non-English speakers, or individuals unable to walk 4 meters or obtain exercise clearance may not receive benefit from this intervention.
Why it matters
Potential benefit: If successful, the program could improve memory and thinking and increase exercise adherence and confidence among older cancer survivors.
How similar studies have performed: Exercise and cognitive rehabilitation have improved cognitive symptoms in cancer and non-cancer populations, and multicomponent programs showed added benefit in older adults without cancer, but combined mobile interventions in older cancer survivors remain relatively untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥60 years at the time of consent * Have a diagnosis of any cancer * Have completed curative intent treatments * Patients on endocrine therapies are allowed to enroll * Patients with hematologic malignancies after autologous or allogeneic stem cell transplant are allowed to enroll as long as they have completed curative-intent treatment * Have concerns about memory or other thinking abilities following cancer treatment\* * English speaking (because the interventions are available in English language only) * Eastern Cooperative Oncology Group (ECOG) performance status of 0-3 * No medical contraindications for exercise per oncologist# * Able to walk 4 meters# * Able to provide informed consent# (\*) Confirmed by asking the patient (#) Confirmed through eligibility confirmation with the patient's oncologist or their designee Exclusion Criteria: * Physical, psychological, or social impairments that would interfere with patient's ability to participate in the study or participate in the intervention, as determined by the PIs and oncology team.
Where this trial is running
Rochester, New York
- University of Rochester — Rochester, New York, United States (Recruiting)
Study contacts
- Principal investigator: Kah Poh Loh — University of Rochester
- Study coordinator: Kah Poh Loh
- Email: Kahpoh_Loh@URMC.Rochester.edu
- Phone: 585-276-4353
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.