Combined kidney and bone marrow transplantation for immune tolerance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the combined transplantation of kidney and bone marrow from HLA-matched sibling donor-recipient pairs to induce immune tolerance, allowing for the potential discontinuation of immunosuppressive therapy without kidney rejection. Hematopoietic stem cells are collected from the donor weeks prior to the kidney transplant, and after the transplant, the recipient undergoes conditioning therapy followed by the infusion of the stem cell graft. The goal is to maintain mixed donor chimerism for over six months, which may enable the tapering off of immunosuppression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age older than 18 years
* Matched siblings
* No contra-indication to thymoglobuline or total lymphoid irradiation

Exclusion Criteria:

* Pregnant women or breast feeding
* Infection with HIV, HBV or HCV
* Previous or presnt malignancy

Where it's running

• Rabin Medical Center
  Petah Tikva, Israel Recruiting

Study contacts

• Principal investigator: Moshe Yeshurun, MD — Institution of Hematology, Rabin Medical Center
• Study coordinator: Moshe Yeshurun, MD
• Email: moshe.yeshurun@gmail.com
• Phone: 0526015543

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pilates exercises to improve balance, fatigue, and quality of life after kidney transplant

  This study tests whether adding Pilates to standard physical therapy helps people aged 20–50 after a kidney transplant feel steadier, less fatigued, and have a better quality of life.

  Recruiting Cairo University · Damanhur, Beheira and 1 other locations · NCT07626086

• Transversalis fascia plane block to reduce pain after kidney transplant

  See if a transversalis fascia plane block can reduce pain and opioid use after kidney transplant for adults aged 18–65 with ASA III.

  Recruiting Ankara Etlik City Hospital · Altındağ, Ankara · NCT07542028

• Preoperative sensory modulation room to reduce pain, anxiety, and improve sleep for living kidney donors and recipients

  The team will try a short preoperative session in a sensory modulation room to see if it lowers postoperative pain, reduces anxiety, and improves sleep for adult living kidney donors and transplant recipients.

  Recruiting Sakarya University · Sakarya · NCT07533669

• Emotion-focused therapy to improve emotion regulation and well-being after kidney transplant

  This project will try an emotion-focused therapy to see if it helps adults who have had a kidney transplant manage their emotions and feel better.

  Recruiting Akdeniz University · Antalya · NCT07294183

• Remimazolam infusion for adults undergoing kidney transplant

  This will test whether a continuous remimazolam infusion gives consistent sedation and predictable blood levels in adults having kidney transplants.

  Recruiting Phase 1 Qianfoshan Hospital · Jinan, Shangdong · NCT07045467

• Comparing muscle function and frailty in kidney transplant recipients

  This study looks at how weak breathing muscles affect the overall health and recovery of people who have received a kidney transplant.

  Recruiting Hacettepe University · Ankara · NCT06706492

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.