Combined DPMAS (double plasma molecular adsorption) and therapeutic plasma exchange to improve clotting, reduce inflammation, and support organs in acute liver failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program delivers artificial liver support by combining a hemoadsorption system (DPMAS) with therapeutic plasma exchange (TPE) for adults with ALF or ACLF in the ICU. The protocol uses double plasma molecular adsorption followed by plasma exchange to remove toxins and inflammatory mediators while replacing plasma components. The primary focus is on effects on coagulation, inflammation, and the function of vital organs to permit liver parenchyma regeneration or to bridge patients to liver transplantation. Eligible participants are adults admitted to the center who are listed for transplant or indicated for support therapy but not for palliative care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient, age ≥18 years
* Expressed consent to the inclusion
* Patient hospitalized on ICU with ALF or ACLF diagnosis
* Recently meeting the inclusion to liver transplantation
* Present on a waiting list to liver transplant
* Unsuitable for inclusion to liver transplantation - indicated for support therapy only, but not indented to palliative care

Exclusion Criteria:

* Disagreement with the study
* Infaust prognosis with expected survival less than 24 hours
* Physiologically/biologically very advanced stage patients condition, severe lung disease (Gold criteria 3 or 4), heart failure (functional class NYHA III or IV) or neurological disease, as well as ACLF-3.
* Advanced oncological disease (expected life expectancy below 6 months)
* Severe degree of Frailty syndrome in secondary severe sarcopenia (muscle and malnutrition) or reduced performance state according

Where it's running

• Institute for Clinical and Experimental Medicine (IKEM)
  Prague, Czechia Recruiting

Study contacts

• Study coordinator: Petr Piza, MD, MHA
• Email: petr.piza@ikem.cz
• Phone: +420 602 225 077

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• N-acetylcysteine for non-acetaminophen-induced acute liver failure

  Researchers are testing whether adding oral N-acetylcysteine to standard care helps adults with non-acetaminophen acute liver failure survive longer compared with standard care alone.

  Recruiting King Edward Medical University · Lahore, Punjab Province · NCT07765823

• Reference framework for outcomes after machine-preserved liver transplantation in Europe

  This study tests how liver transplants that use machine perfusion perform in real-world practice, to see how different perfusion methods relate to outcomes for adults in Europe.

  Recruiting at 4 sites University Medical Center Groningen · Innsbruck and 37 other locations · NCT07585890

• Standard-volume versus high-volume plasma exchange for children with acute liver failure

  This trial will see if using high-volume plasma exchange instead of standard-volume plasma exchange helps children (ages 3–18) with acute liver failure keep their native liver.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT06831643

• F573 injection for treating liver injury and failure

  This study is testing if an injection called F573 can help people with liver injury or chronic hepatitis B feel better and recover.

  Recruiting at 10 sites Phase 2 Beijing Continent Pharmaceutical Co, Ltd. · Beijing, Beijing Municipality and 9 other locations · NCT05689645

• Registry for monitoring CytoSorb device use in critically ill patients

  This study is collecting information on how the CytoSorb device helps critically ill patients to improve care for conditions like septic shock and acute respiratory distress syndrome.

  Recruiting at 24 sites CytoSorbents, Inc · Klagenfurt and 27 other locations · NCT05146336

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.