Collection of genetic samples for liver disease research
Genetic Collection Protocol
Arbor Research Collaborative for Health · NCT05272319
This study is collecting blood or saliva samples from children with liver diseases and their parents to help researchers learn more about these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2230 (estimated) |
| Ages | 24 Hours to 25 Years |
| Sex | All |
| Sponsor | Arbor Research Collaborative for Health (other) |
| Locations | 13 sites (Los Angeles, California and 12 other locations) |
| Trial ID | NCT05272319 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect whole blood or saliva samples from children with liver diseases and their biological parents who have previously participated in ChiLDReN-supported protocols. The collected genetic biosamples will be linked to existing data from earlier studies and stored in the NIDDK specimen repository. These samples will be utilized in ongoing and future studies to enhance understanding of the pathophysiology and outcomes associated with liver diseases.
Who should consider this trial
Good fit: Ideal candidates include children who have previously participated in ChiLDReN studies and their biological parents who have not yet provided a DNA sample.
Not a fit: Patients who are deceased or who exited prior studies due to eligibility violations will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable genetic insights that improve the understanding and treatment of liver diseases in children.
How similar studies have performed: Other studies involving genetic sample collection for chronic diseases have shown success in advancing research, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* For Child Participants
1. Previous enrollment in PROBE or BASIC
2. Exited from one of the aforementioned studies.
3. Consent for DNA sample collection obtained during enrollment during enrollment to one of the aforementioned studies but sample not previously collected.
4. Still followed at the clinical site.
Exclusion Criteria:
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1. Participant is deceased
2. Participant exited from prior study due to violating eligibility criteria
3. Participant cannot be contacted
Where this trial is running
Los Angeles, California and 12 other locations
- Children's Hospital of Los Angeles — Los Angeles, California, United States (RECRUITING)
- UCSF Benioff Children's Hospital — San Francisco, California, United States (COMPLETED)
- Children's Hospital Colorado — Aurora, Colorado, United States (RECRUITING)
- Children's Healthcare of Atlanta — Atlanta, Georgia, United States (RECRUITING)
- Lurie Children's Hospital — Chicago, Illinois, United States (RECRUITING)
- Riley Hospital for Children — Indianapolis, Indiana, United States (COMPLETED)
- Cincinnati Children's Hospital — Cincinnati, Ohio, United States (RECRUITING)
- The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (RECRUITING)
- UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States (RECRUITING)
- Texas Children's Hospital; Baylor College of Medicine — Houston, Texas, United States (RECRUITING)
- University of Utah — Salt Lake City, Utah, United States (RECRUITING)
- Seattle Children's Hospital — Seattle, Washington, United States (RECRUITING)
- The Hospital for Sick Children — Toronto, Ontario, Canada (COMPLETED)
Study contacts
- Principal investigator: John Magee, MD — University of Michigan
- Study coordinator: Terese A Howell, BS
- Email: terri.howell@aborresearch.org
- Phone: 734-476-5340
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Liver Diseases