Collection of biological samples for neurological syndromes
Official title: Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Run by Hospices Civils de Lyon · NCT05198661 · Data updated 2026-11-12
This study is collecting samples from people with Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis to see if it can help improve how these conditions are diagnosed and treated.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 3500 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 62 sites (Pointe à Pitre, Guadeloupe and 61 other locations) |
| Status | Recruiting |
| Started | August 2, 2022 |
| Main results expected | August 2, 2032 |
| Study ends | August 2, 2032 |
| Registry record updated | February 29, 2024 |
| Trial ID | NCT05198661 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with well-characterized antibodies in their serum or cerebrospinal fluid and a neurological disorder compatible with PNS or AE.
✕Probably not a fit
Patients who refuse consent or are under guardianship will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on collecting biological samples from patients diagnosed with Paraneoplastic Neurological Syndromes (PNS) or Autoimmune Encephalitis (AE) to improve diagnosis and treatment options. By gathering sera, cerebrospinal fluid, and other biological materials, the study aims to enhance understanding of these rare neuroimmune disorders. The goal is to facilitate faster and more accurate diagnoses, ultimately leading to better patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods and treatment strategies for patients with rare neuroimmune syndromes.
How similar studies have gone: While this approach is focused on biological sample collection, similar studies have shown promise in improving diagnosis and treatment for neuroimmune disorders.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with consent * Patient with well-characterized antibodies in serum or cerebrospinal fluid or not * Patient with neurological disorder compatible with PNS or auto-immune encephalitis Exclusion Criteria: * Refusal of consent * Patient under guardianship
Where it's running
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Neurology
Besançon, France Recruiting -
Neurology
Épinal, France Recruiting -
Neurologie
Grenoble, France Recruiting -
Neurology
Lille, France Recruiting -
Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites autoimmunes
Lyon, France Recruiting -
Neurology
Pointe à Pitre, Guadeloupe, France Not yet recruiting
Show 44 more locations
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Neurology
Aix-en-Provence, France Not yet recruiting -
Neurologie
Amiens, France Not yet recruiting -
Neurology
Angers, France Not yet recruiting -
General neurology
Annecy, France Not yet recruiting -
Neurology
Avignon, France Not yet recruiting -
Neurologie
Bayonne, France Not yet recruiting -
Neurology
Bobigny, France Not yet recruiting -
Neurology
Bordeaux, France Not yet recruiting -
Neurology
Brest, France Not yet recruiting -
Intensive care medicine
Cannes, France Not yet recruiting -
Neurologie
Chambéry, France Not yet recruiting -
Neurology
Clermont-Ferrand, France Not yet recruiting -
Neurologie
Colmar, France Not yet recruiting -
Neurology
Créteil, France Not yet recruiting -
General, Vascular and Degenerative Neurology
Dijon, France Not yet recruiting -
Internal and general practitioner
Gap, France Not yet recruiting -
Neurology
La Roche-sur-Yon, France Not yet recruiting -
Neurology
Lille, France Not yet recruiting -
Neurology
Limoges, France Not yet recruiting -
Neurology
Lisieux, France Not yet recruiting -
Adult Neurology and Neuropsychology
Marseille, France Not yet recruiting -
Neurologie
Marseille, France Not yet recruiting -
Neurology
Marseille, France Not yet recruiting -
Neurology
Mâcon, France Not yet recruiting -
Neurology
Metz, France Not yet recruiting -
Neurology
Montivilliers, France Not yet recruiting -
General Neurology
Montpellier, France Not yet recruiting -
General medicine
Mulhouse, France Not yet recruiting -
Neurologie
Nancy, France Not yet recruiting -
Neurology
Nantes, France Not yet recruiting -
Neurologie
Nice, France Not yet recruiting -
Neurology
Nîmes, France Not yet recruiting -
Neurology
Paris, France Not yet recruiting -
Neuropediatrics
Paris, France Not yet recruiting -
Intensive Care Medicine
Paris, France Not yet recruiting -
Neurology
Paris, France Not yet recruiting -
Onco-neurology
Paris, France Not yet recruiting -
Neurology adult
Paris, France Not yet recruiting -
Neurology, neuropsychology and language rehabilitation
Poitiers, France Not yet recruiting -
Neurology
Reims, France Not yet recruiting -
Neurology
Rennes, France Not yet recruiting -
Vascular and general neurology
Rouen, France Not yet recruiting -
Neurology
Saint-Brieuc, France Not yet recruiting -
Neurology
Saint-Denis, France Not yet recruiting
+12 more sites. See ClinicalTrials.gov for the full list.
Study contacts
- Study coordinator: Jerome HONNORAT, Pr
- Email: jerome.honnorat@chu-lyon.fr
- Phone: 4 72 35 78 06
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Liquid biopsy to detect tumor cells and tumor DNA in people with paraneoplastic neurological syndromes.
This project tests whether a large blood collection (diagnostic leukapheresis) plus sensitive lab tests can find circulating tumor cells or tumor DNA in adults with paraneoplastic neurological syndromes, whether or not a tumor is already known.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.