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Collection of biological samples for neurological syndromes

Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection

Not applicable Interventional Hospices Civils de Lyon · NCT05198661

This study is collecting samples from people with Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis to see if it can help improve how these conditions are diagnosed and treated.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment3500 (estimated)
SexAll
SponsorHospices Civils de Lyon Academic / other
Locations62 sites (Pointe à Pitre, Guadeloupe and 61 other locations)
Trial IDNCT05198661 on ClinicalTrials.gov

What this trial studies

This study focuses on collecting biological samples from patients diagnosed with Paraneoplastic Neurological Syndromes (PNS) or Autoimmune Encephalitis (AE) to improve diagnosis and treatment options. By gathering sera, cerebrospinal fluid, and other biological materials, the study aims to enhance understanding of these rare neuroimmune disorders. The goal is to facilitate faster and more accurate diagnoses, ultimately leading to better patient outcomes.

Who should consider this trial

Good fit: Ideal candidates include patients with well-characterized antibodies in their serum or cerebrospinal fluid and a neurological disorder compatible with PNS or AE.

Not a fit: Patients who refuse consent or are under guardianship will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic methods and treatment strategies for patients with rare neuroimmune syndromes.

How similar studies have performed: While this approach is focused on biological sample collection, similar studies have shown promise in improving diagnosis and treatment for neuroimmune disorders.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Patient with consent
* Patient with well-characterized antibodies in serum or cerebrospinal fluid or not
* Patient with neurological disorder compatible with PNS or auto-immune encephalitis

Exclusion Criteria:

* Refusal of consent
* Patient under guardianship

Where this trial is running

Pointe à Pitre, Guadeloupe and 61 other locations

+12 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Paraneoplastic Neurological Syndromes or Autoimmune EncephalitisParaneoplastic Neurological SyndromesAutoimmune Encephalitisbiological collection
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.