Collecting tumor specimens to improve cancer treatment
Patient Derived Preclinical Models
Mayo Clinic · NCT05324553
This study is collecting tumor and blood samples from cancer patients to help researchers better understand cancer and find new treatments that could improve patient care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic (other) |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT05324553 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect tumor specimens, matched normal tissue when possible, and blood samples from cancer patients to enhance understanding of cancer biology. The collected specimens will be used to develop patient-derived preclinical models, including cell lines and xenografts, which will help in testing new therapies and identifying targetable alterations in tumors. Genomic and proteomic profiling may be employed to analyze the tumor samples, guiding future therapeutic strategies and clinical trials. The study emphasizes collaboration and aims to provide insights that could lead to improved patient outcomes in cancer treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are good medical candidates for a biopsy or surgical procedure to obtain tumor tissue.
Not a fit: Patients with uncontrolled illnesses, significant coagulopathy, or those who cannot provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the development of novel therapeutic strategies that improve outcomes for patients with cancer.
How similar studies have performed: Other studies utilizing patient-derived preclinical models have shown promise in advancing cancer research and treatment strategies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age and older * Patient is a good medical candidate for a standard of care or research biopsy or surgical procedure to obtain tissue Exclusion Criteria: * Uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent * Institutionalized or incarcerated patients * Inaccessible tumor for biopsy or patient does not have tumor tissue available for research use * Biopsy must not be considered more than minimal risk to the patient. * Have a contraindication to percutaneous biopsy including: 1. Significant coagulopathy that cannot be adequately corrected. 2. Severely compromised cardiopulmonary function or hemodynamic instability. 3. Lack of a safe pathway to the lesion per the interventional radiologist. 4. Inability of the patient to cooperate with, or to be positioned for, the procedure.
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (RECRUITING)
Study contacts
- Principal investigator: Aaron S. Mansfield, M.D. — Mayo Clinic
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cancer