Collecting tissue samples from patients with malignant pleural effusion
Creation of a Pleural Carcinomatosis Tissue Bank
This study is collecting tissue samples from adults with malignant pleural effusion to see how the cancer cells in the fluid differ from the original tumor cells, which could help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 110 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Bron) |
| Trial ID | NCT04844827 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with malignant pleural effusion, a condition often resulting from various cancers, including lung, breast, ovarian, and gastric cancers. The study aims to collect pleural biopsy samples to analyze the genetic and molecular characteristics of metastatic cells, which may differ from the original tumor cells. By understanding these differences, researchers hope to improve treatment strategies and patient outcomes. Participants must be over 18 years old and eligible for a pleural biopsy, providing informed consent for their tissue to be used in future analyses.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 with malignant pleural effusion who are eligible for a pleural biopsy.
Not a fit: Patients with malignant pleural mesothelioma or those contraindicated for general anesthesia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment options for patients with malignant pleural effusion.
How similar studies have performed: While similar studies have explored tissue banking and molecular profiling, this specific approach to malignant pleural effusion is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female over 18 years old * Malignant pleural effusion with or without prior histological or cytological diagnosis * Patient eligible for a pleural biopsy for diagnostic purposes and validated in a multidisciplinary consultation meeting * Having given their free and informed writing consent * Affiliated to a social security system or assimilated Exclusion Criteria: * Malignant pleural mesothelioma * Contraindication to general anesthesia * Pregnant or breastfeeding woman, or is of child bearing potential and who did not agree to use highly effective methods of birth control throughout the study. * Patient participating in a interventional study likely to interfere with this study * Patient benefiting from a legal protection measure (guardianship or curatorship)
Where this trial is running
Bron
- Louis Pradel Hospital — Bron, France (Recruiting)
Study contacts
- Principal investigator: Gabrielle Drevet, MD — Department of Thoracic Surgery - Louis Pradel Hospital
- Study coordinator: Gabrielle Drevet, MD
- Email: gabrielle.drevet@chu-lyon.fr
- Phone: 04 72 35 75 54
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.