Collecting samples from people with respiratory virus infections

Respiratory Virus Sampling and Repository

Observational National Institutes of Health Clinical Center (CC) · NCT05266222

This study is collecting blood and nasal samples from people aged 3 and older who have respiratory virus infections to help researchers learn more about these viruses and improve vaccines and treatments.

Quick facts

Study typeObservational
Enrollment20000 (estimated)
Ages3 Years and up
SexAll
SponsorNational Institutes of Health Clinical Center (CC) NIH
Locations2 sites (Bethesda, Maryland and 1 other locations)
Trial IDNCT05266222 on ClinicalTrials.gov

What this trial studies

This observational study aims to gather samples from individuals aged 3 and older who have or are suspected to have respiratory virus infections, such as influenza and COVID-19. Participants will provide blood and nasal samples, and data from their medical records will be collected. The samples will be used to study respiratory viruses and the immune responses to them, contributing to future research on vaccines and treatments. The study will take place over a duration of 10 years at the NIH Clinical Center.

Who should consider this trial

Good fit: Ideal candidates include individuals aged 3 and older with documented or suspected respiratory virus infections.

Not a fit: Patients who do not have a respiratory virus infection or have conditions that compromise their safety may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance our understanding of respiratory viruses and improve future vaccine and treatment development.

How similar studies have performed: Other studies have successfully collected respiratory virus samples for research, indicating that this approach is viable and beneficial.

Eligibility criteria

Show full inclusion / exclusion criteria
* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Aged 3 years or older.
2. Documented or suspected infection with a respiratory virus.
3. Stated willingness to comply with all study procedures for the duration of the study.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1\. Any condition that, in the opinion of the investigator, would compromise the safety of the study participant or staff, or would prevent proper conduct of the study.

Non-English Speaking Participants: This study will enroll non-English speaking participants.

For non-English speaking participants, the study will be explained to the participant/family through an interpreter, in the presence of the study team, in the language understood by the participant/family. The short form in the language understood by the participant/family will be signed by the participant/family or LAR and the interpreter, and the consent will be signed by the consenting provider and the interpreter.

Where this trial is running

Bethesda, Maryland and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions InfluenzaCOVID-19FluCOVIDCoronavirusImmunityNatural History
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.